About: End-Organ Damage in Hypertensive Transgenic Ren-2 Rats: Influence of Early and Late Endothelin Receptor Blockade

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: End-Organ Damage in Hypertensive Transgenic Ren-2 Rats: Influence of Early and Late Endothelin Receptor Blockade Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The rat strain transgenic for the murine Ren-2 renin gene (TGR) is defined as a monogenic model of angiotensin II-dependent hypertension with endogenous activation of the renin-angiotensin system. Homozygous males TGR develop malignant hypertension with a strong salt-sensitive component. These animals show severe hypertension, proteinuria and high mortality. Morphological changes of renal parenchyma correspond to chronic ischemic glomerular changes. Heterozygous TGR develop only mild hypertension and thus provide a more suitable model of hypertension regarding to clinical studies. Within the renal parenchyma, secondary focal segmental glomerulosclerosis (FSGS) predominates. High-salt diet in heterozygous animals induces transition from benign to malignant phase of hypertension. In this case, ischemic glomerular changes are superimposed on preexisting secondary FSGS. In the regression model of hypertension (late-onset treatment) the effect of salt intake is attenuated. In homozygous TGR, early selectiv The rat strain transgenic for the murine Ren-2 renin gene (TGR) is defined as a monogenic model of angiotensin II-dependent hypertension with endogenous activation of the renin-angiotensin system. Homozygous males TGR develop malignant hypertension with a strong salt-sensitive component. These animals show severe hypertension, proteinuria and high mortality. Morphological changes of renal parenchyma correspond to chronic ischemic glomerular changes. Heterozygous TGR develop only mild hypertension and thus provide a more suitable model of hypertension regarding to clinical studies. Within the renal parenchyma, secondary focal segmental glomerulosclerosis (FSGS) predominates. High-salt diet in heterozygous animals induces transition from benign to malignant phase of hypertension. In this case, ischemic glomerular changes are superimposed on preexisting secondary FSGS. In the regression model of hypertension (late-onset treatment) the effect of salt intake is attenuated. In homozygous TGR, early selectiv (en)
Title	End-Organ Damage in Hypertensive Transgenic Ren-2 Rats: Influence of Early and Late Endothelin Receptor Blockade End-Organ Damage in Hypertensive Transgenic Ren-2 Rats: Influence of Early and Late Endothelin Receptor Blockade (en)
skos:prefLabel	End-Organ Damage in Hypertensive Transgenic Ren-2 Rats: Influence of Early and Late Endothelin Receptor Blockade End-Organ Damage in Hypertensive Transgenic Ren-2 Rats: Influence of Early and Late Endothelin Receptor Blockade (en)
skos:notation	RIV/00216208:11120/09:00001693!RIV10-GA0-11120___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GC305/07/J004)
http://linked.open...iv/cisloPeriodika	Suppl. 2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kujal, Petr Vernerová, Zdeňka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	313167
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/09:00001693
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Endothelin receptors; Hypertension; Morphology; Podocytes; Ren-2 rats (en)
http://linked.open.../riv/klicoveSlovo	Podocytes Morphology Hypertension Ren-2 rats Endothelin receptors
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[7FDC5E46D718]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	The roles of renin-angiotensin and endothelin systems in the pathophysiology of ANG II-dependent hypertension
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	58
http://linked.open...iv/tvurceVysledku	Červenka, L. Kramer, H. J. Kujal, Petr Vernerová, Zdeňka Backer, A. Vaněčková, I.
http://linked.open...ain/vavai/riv/wos	000273537200007
issn	0862-8408
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	End-Organ Damage in Hypertensive Transgenic Ren-2 Rats: Influence of Early and Late Endothelin Receptor Blockade End-Organ Damage in Hypertensive Transgenic Ren-2 Rats: Influence of Early and Late Endothelin Receptor Blockade End-Organ Damage in Hypertensive Transgenic Ren-2 Rats: Influence of Early and Late Endothelin Receptor Blockade End-Organ Damage in Hypertensive Transgenic Ren-2 Rats: Influence of Early and Late Endothelin Receptor Blockade

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software