About: Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this study was to compare the expression of proteins potentially involved in non-transferrin iron transport across membranes (DMT1, Dcytb, ferroportin, hephaestin, and ceruloplasmin) in various types of human cells (Caco-2, K562 and HEP-G2) under extracellular iron deficiency and excess of extracellular non-transferrin iron. We demonstrated that changes in iron availability, i.e. iron deficiency and iron excess, affect the expression of DMT1, Dcytb, ferroportin, hephaestin and ceruloplasmin on mRNA as well as on protein level in a cell type-specific manner. The aim of this study was to compare the expression of proteins potentially involved in non-transferrin iron transport across membranes (DMT1, Dcytb, ferroportin, hephaestin, and ceruloplasmin) in various types of human cells (Caco-2, K562 and HEP-G2) under extracellular iron deficiency and excess of extracellular non-transferrin iron. We demonstrated that changes in iron availability, i.e. iron deficiency and iron excess, affect the expression of DMT1, Dcytb, ferroportin, hephaestin and ceruloplasmin on mRNA as well as on protein level in a cell type-specific manner. (en) Cílem práce bylo porovnat expresi proteinů účastnících se transportu netransferinového železa přes membrány (DMT1, Dcytb, ferroportin, hephaestin, a ceruloplasmin) u různých typů lidských buněk (Caco-2, K562 and HEP-G2) pod vlivem deprivace a nadbytku extracelulárního netransferinového železa. Ukázali jsme, že změny v dostupnosti železa, tj. deprivace železa a nadbytek železa, ovlivňují expresi DMT1, Dcytb, ferroportinu, hephaestinu a ceruloplasminu na úrovni mRNA i proteinů v závislosti na daném typu buněk. (cs)
Title	Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess (en) Rozdílná exprese genů zúčastněných v transportu netransferinového železa přes plazmatickou membránu u různých typů buněk pod vlivem deprivace a nadbytku železa (cs)
skos:prefLabel	Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess (en) Rozdílná exprese genů zúčastněných v transportu netransferinového železa přes plazmatickou membránu u různých typů buněk pod vlivem deprivace a nadbytku železa (cs)
skos:notation	RIV/00216208:11120/09:00000488!RIV09-MSM-11120___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620814)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Neubauerová, Jitka Kovář, Jan Horák, Jiří Balušíková, Kamila Dostalíková-Čimburová, Markéta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	310513
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/09:00000488
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Non-transferrin iron transport; DMT1; Dcytb; Ferroportin; Hephaestin; Ceruloplasmin (en)
http://linked.open.../riv/klicoveSlovo	Ferroportin Ceruloplasmin DMT1 Dcytb Hephaestin Non-transferrin iron transport
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[CC09B13863D2]
http://linked.open...i/riv/nazevZdroje	Molecular and Cellular Biochemistry
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	321
http://linked.open...iv/tvurceVysledku	Horák, Jiří Kovář, Jan Neubauerová, Jitka Dostalíková-Čimburová, Markéta Balušíková, Kamila
http://linked.open...ain/vavai/riv/wos	000262402500013
http://linked.open...n/vavai/riv/zamer	Prevention, diagnostics and therapy of diabetes mellitus, metabolic and endocrine damage of organism
issn	0300-8177
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess

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