About: BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder

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About: BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Brain-derived neurotrophic factor (BDNF) is a key factor in neuroplasticity and has been implicated in the affective disorders; studies have demonstrated elevated BDNF in patients taking lithium and other mood stabilizers. The objective of our study was to analyze BDNF in lithium-responsive patients with bipolar disorder (BD) to further understand the role of BDNF in the pathophysiology of BD. Methods: Using enzyme-linked immunosorbent assay, we measured transformed B lymphocytes for BDNF protein. Results: BDNF levels were 36% lower in lymphoblasts from patients with BD (n = 12), compared with matched control participants (n = 13), and 55% lower when compared with their unaffected relatives (n = 14). Lithium significantly decreased BDNF levels in patients with BD and healthy control participants, although BDNF levels remained lower (33%) in the BID group posttreatment. Conclusion: Decreased BDNF may constitute part of the pathophysiologic process of BID in a lithium-responsive subgroup of individuals with this disease. A compensatory mechanism protecting the genetically predisposed unaffected relatives from phenotypic expression of BID is suggested. Brain-derived neurotrophic factor (BDNF) is a key factor in neuroplasticity and has been implicated in the affective disorders; studies have demonstrated elevated BDNF in patients taking lithium and other mood stabilizers. The objective of our study was to analyze BDNF in lithium-responsive patients with bipolar disorder (BD) to further understand the role of BDNF in the pathophysiology of BD. Methods: Using enzyme-linked immunosorbent assay, we measured transformed B lymphocytes for BDNF protein. Results: BDNF levels were 36% lower in lymphoblasts from patients with BD (n = 12), compared with matched control participants (n = 13), and 55% lower when compared with their unaffected relatives (n = 14). Lithium significantly decreased BDNF levels in patients with BD and healthy control participants, although BDNF levels remained lower (33%) in the BID group posttreatment. Conclusion: Decreased BDNF may constitute part of the pathophysiologic process of BID in a lithium-responsive subgroup of individuals with this disease. A compensatory mechanism protecting the genetically predisposed unaffected relatives from phenotypic expression of BID is suggested. (en)
Title	BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder (en)
skos:prefLabel	BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder (en)
skos:notation	RIV/00216208:11120/08:43906867!RIV13-MSM-11120___
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Alda, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	357707
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/08:43906867
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lithium; enzyme-linked immunosorbent assay; brain-derived neurotrophic factor; bipolar disorder (en)
http://linked.open.../riv/klicoveSlovo	enzyme-linked immunosorbent assay lithium bipolar disorder brain-derived neurotrophic factor
http://linked.open...odStatuVydavatele	CA - Kanada
http://linked.open...ontrolniKodProRIV	[7A782E09C35E]
http://linked.open...i/riv/nazevZdroje	Journal of Psychiatry & Neuroscience
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	33
http://linked.open...iv/tvurceVysledku	Alda, Martin
http://linked.open...ain/vavai/riv/wos	000259500500008
issn	1180-4882
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder

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