About: Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.schres.2008.04.013
Description	Cadherins and protocadherins are cell adhesion proteins that play an important role in neuronal migration, differentiation and synaptogenesis, properties that make them targets to consider in schizophrenia (SZ) and bipolar disorder (BD) pathogenesis. Consequently, allelic variation occurring in protocadherin and cadherin encoding genes that map to regions of the genome targeted in SZ and BD linkage studies are particularly strong candidates to consider. One such set of candidate genes is the 5q31-linked PCDH family, which consists of more than 50 exons encoding three related, though distinct family members - alpha, beta, and gamma - which can generate thousands of different protocadherin proteins through alternative promoter usage and cis-alternative splicing. In this study, we focused on a SNP, rs31745, which is located in a putative PCDH alpha enhancer mapped by ChIP-chip using antibodies to covalently modified histone H3. Cadherins and protocadherins are cell adhesion proteins that play an important role in neuronal migration, differentiation and synaptogenesis, properties that make them targets to consider in schizophrenia (SZ) and bipolar disorder (BD) pathogenesis. Consequently, allelic variation occurring in protocadherin and cadherin encoding genes that map to regions of the genome targeted in SZ and BD linkage studies are particularly strong candidates to consider. One such set of candidate genes is the 5q31-linked PCDH family, which consists of more than 50 exons encoding three related, though distinct family members - alpha, beta, and gamma - which can generate thousands of different protocadherin proteins through alternative promoter usage and cis-alternative splicing. In this study, we focused on a SNP, rs31745, which is located in a putative PCDH alpha enhancer mapped by ChIP-chip using antibodies to covalently modified histone H3. (en)
Title	Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia (en)
skos:prefLabel	Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia (en)
skos:notation	RIV/00216208:11120/08:00003125!RIV12-MZ0-11120___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR8564)
http://linked.open...iv/cisloPeriodika	1-3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Novák, Tomáš Stopková, Pavla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	355871
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/08:00003125
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	protocadherin; cadherin schizophrenia; bipolar disorder; chromatin (en)
http://linked.open.../riv/klicoveSlovo	chromatin cadherin schizophrenia protocadherin bipolar disorder
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[8D17AC238535]
http://linked.open...i/riv/nazevZdroje	Schizophrenia Research
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	THE ROLE OF PHOSPHOINOSITIDE PATHWAY IN SUSCEPTIBILITY TO BIPOLAR AFFECTIVE DISORDER
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	102
http://linked.open...iv/tvurceVysledku	Novák, Tomáš Stopková, Pavla
http://linked.open...ain/vavai/riv/wos	000257837700024
issn	0920-9964
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.schres.2008.04.013
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia

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