About: Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1097/YPG.0b013e3282fa1838
Description	The cell adhesion proteins cadherins and protocadherins, through their effects on neuronal differentiation, synaptogenesis, and brain development, are feasible targets to consider in schizophrenia (SZ) and bipolar disorder (BD) pathogenesis. Allelic variation occurring in protocadherin and cadherin encoding genes that map to regions of the genome targeted in SZ and BD linkage studies are particularly strong candidates to consider as underlying susceptibility factors. One such set of candidate genes is the 5q31-linked PCDH family. A polymorphic copy number variation in this locus, a 16.7 kilobase (kb) deletion affecting PCDH- alpha exons 8-10 (alpha 8- alpha 10 Delta), was analyzed in this study in a cohort of European Caucasian patients with SZ and a cohort of patients with BD from the Czech Republic, and corresponding controls. No differences in allele distribution were detected in either group. While theoretical considerations and linkage studies suggest that the 5q31-linked PCDH genes should be vi The cell adhesion proteins cadherins and protocadherins, through their effects on neuronal differentiation, synaptogenesis, and brain development, are feasible targets to consider in schizophrenia (SZ) and bipolar disorder (BD) pathogenesis. Allelic variation occurring in protocadherin and cadherin encoding genes that map to regions of the genome targeted in SZ and BD linkage studies are particularly strong candidates to consider as underlying susceptibility factors. One such set of candidate genes is the 5q31-linked PCDH family. A polymorphic copy number variation in this locus, a 16.7 kilobase (kb) deletion affecting PCDH- alpha exons 8-10 (alpha 8- alpha 10 Delta), was analyzed in this study in a cohort of European Caucasian patients with SZ and a cohort of patients with BD from the Czech Republic, and corresponding controls. No differences in allele distribution were detected in either group. While theoretical considerations and linkage studies suggest that the 5q31-linked PCDH genes should be vi (en)
Title	Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia (en)
skos:prefLabel	Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia (en)
skos:notation	RIV/00216208:11120/08:00003114!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	I Z
http://linked.open...avai/riv/aktivity	I, Z(MZ0PCP2005)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Novák, Tomáš Stopková, Pavla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	355870
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/08:00003114
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	protokadherin; schizophrenia; bipolar disorder; copy number variation (en)
http://linked.open.../riv/klicoveSlovo	copy number variation schizophrenia protokadherin bipolar disorder
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[AA37C8914FF8]
http://linked.open...i/riv/nazevZdroje	Psychiatric Genetics
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	18
http://linked.open...iv/tvurceVysledku	Novák, Tomáš Stopková, Pavla Lachman, Herbert M.
http://linked.open...ain/vavai/riv/wos	000256125300002
http://linked.open...n/vavai/riv/zamer	Study of Sources f Psychiatric Morbidity , and Increasing the Effec-tiveness of the Preventative and Therapeutical methods in mental Health Care in the Czech Republic 2005?2011
issn	0955-8829
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1097/YPG.0b013e3282fa1838
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia

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