| Attributes | Values |
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| rdf:type
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| Description
| - Imunoterapie interferonem alfa je standardem léčby u rizikového maligního melanomu stádia IIB-III. Ve studii byla použita metoda multimarkerové RT-PCR v reálném čase pro kvantitativní detekci cirkulujících nádorových buněk u pacientů s melanomem. Pro sledování byly vybrány 4 markery - gp 100, MIA, tyrozináza a MAGE-3. V publikaci výsledky naznačují, že hladina cirkujících melanomových buněk úzce souvisí s úspěšností této léčby. (cs)
- Standard screening of melanoma patients is a useful tool for predicting outcome of patients, however, an instant methodology for exact detection of subclinical disease or monitoring treatment response is under investigation. Detection of circulating melanoma cells is, therefore, a possible novel promising staging method. However, inconsistent data on method sensitivity and on the predicted patient outcome has been shown repeatedly. Recently, a multimarker real-time RT-PCR methodology for quantification of five melanoma markers Melan-A, gp 100, MAGE-3, MIA and tyrosinase was described by our group. In the current prospective trial, blood specimens of 65 patients with AJCC stage IIB-III cutaneous melanoma after surgery were periodically examined. In the above group, 27 % of subjects relapsed during the study. Prior to the disease progression we could observe a statistically significant tumor marker elevation in previous 0 to 9 months in all patients with clinical relapse. MAGE-3 became the most sensitiv
- Standard screening of melanoma patients is a useful tool for predicting outcome of patients, however, an instant methodology for exact detection of subclinical disease or monitoring treatment response is under investigation. Detection of circulating melanoma cells is, therefore, a possible novel promising staging method. However, inconsistent data on method sensitivity and on the predicted patient outcome has been shown repeatedly. Recently, a multimarker real-time RT-PCR methodology for quantification of five melanoma markers Melan-A, gp 100, MAGE-3, MIA and tyrosinase was described by our group. In the current prospective trial, blood specimens of 65 patients with AJCC stage IIB-III cutaneous melanoma after surgery were periodically examined. In the above group, 27 % of subjects relapsed during the study. Prior to the disease progression we could observe a statistically significant tumor marker elevation in previous 0 to 9 months in all patients with clinical relapse. MAGE-3 became the most sensitiv (en)
|
| Title
| - Early detection of melanoma progression by quantitative real-time RT-PCR analysis for multiple melanoma markers
- Včasná detekce progrese melanomu kvantitativní RT-PCR v reálném čase pomocí několika melanomových markerů (cs)
- Early detection of melanoma progression by quantitative real-time RT-PCR analysis for multiple melanoma markers (en)
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| skos:prefLabel
| - Early detection of melanoma progression by quantitative real-time RT-PCR analysis for multiple melanoma markers
- Včasná detekce progrese melanomu kvantitativní RT-PCR v reálném čase pomocí několika melanomových markerů (cs)
- Early detection of melanoma progression by quantitative real-time RT-PCR analysis for multiple melanoma markers (en)
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| skos:notation
| - RIV/00216208:11120/08:00001261!RIV09-MZ0-11120___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/08:00001261
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - malignant melanoma; melanoma markers; circulating melanoma cells (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Arenberger, Petr
- Arenbergerová, Monika
- Křemen, Jaromír
- Vohradníková, Olga
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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