About: Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity

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About: Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Analyzovali jsme transkriptom podkožní tukové tkáně u obesních jedinců, v situaci stabilizované váhy a po redukcí váhy po bariatrické operaci. Analyza ukázala významnou positivní regulaci genů a biologických struktur, které mají vztah ke složkám extracelulární matrix (ECM), včetně členů skupiny integrinů, nasvědčuje tomu, že tyto prvky mohou hrát důležitou zprostředkující roli v řetězci interakcí spojujících lokální zánětlivé jevy se změnami metabolické funkce bílé tukové tkáně u obesních jedinců. (cs) We analyzed the transcriptomic signature of the subcutaneous in obese human subjects, in stable weight conditions and after weight loss following bariatric surgery. The analyses highlighted a significant up-regulation of genes and biological themes related to extracellular matrix (ECM) constituents, including members of the integrin family, and suggested that these elements could play a major mediating role in a chain of interactions that connect local inflammatory phenomena to the alteration of white adipose tissue metabolic functions in obese subjects. We analyzed the transcriptomic signature of the subcutaneous in obese human subjects, in stable weight conditions and after weight loss following bariatric surgery. The analyses highlighted a significant up-regulation of genes and biological themes related to extracellular matrix (ECM) constituents, including members of the integrin family, and suggested that these elements could play a major mediating role in a chain of interactions that connect local inflammatory phenomena to the alteration of white adipose tissue metabolic functions in obese subjects. (en)
Title	Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity Transkriptom tukové tkáně prokazuje patologický význam extracelulární matrix u lidské obezity (cs) Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (en)
skos:prefLabel	Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity Transkriptom tukové tkáně prokazuje patologický význam extracelulární matrix u lidské obezity (cs) Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (en)
skos:notation	RIV/00216208:11120/08:00001146!RIV09-MSM-11120___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620814)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Štich, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	354933
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/08:00001146
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Gene-Expression; Liver Fibrosis; Weight-Loss; Interaction Networks; Pulmonary-Fibrosis; Microarray Data; Energy-Balance; Up-Regulation; In-Vivo; Inflammation (en)
http://linked.open.../riv/klicoveSlovo	Gene-Expression Inflammation Energy-Balance In-Vivo Interaction Networks Liver Fibrosis Microarray Data Pulmonary-Fibrosis Up-Regulation Weight-Loss
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[8DAEDF114E39]
http://linked.open...i/riv/nazevZdroje	Genome Biology
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Štich, Vladimír Henegar, C. Langin, D. Viguerie, N. Achard, V. Basdevant, A. Bedossa, P. Clement, K. Cremer, I. Guerre-Millo, M. Lacasa, D. Poitou, C. Tordjman, J. Zucker, J.D..
http://linked.open...ain/vavai/riv/wos	000253779800022
http://linked.open...n/vavai/riv/zamer	Prevention, diagnostics and therapy of diabetes mellitus, metabolic and endocrine damage of organism
issn	1474-760X
number of pages	32 (xsd:int)
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity

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