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| Description
| - Recesivní dystrofická epidermolyza bulozní (RDEB) má zvýšené riziko vzniku progresivního a metastazujícího spinocelulárního karcinomu kůže (SCC). Není jasné, proč tyto karcinomy jsou agresivnější než ojediněle se vyskytující. Matrix metalloproteniaz patří mezi endopeptidasy, které podporují růst, invazi a metastazují. Role MMP u SCC u recesisní dystrofické epidermolyzy bulozní není známa. Cílem práce je zkoumat expresi MMP-7, MMP-13 a MMP-9 u RDEB ve srovnání se sporadickým SCC a nemocí Bowen. K Immunohistochemické analyze byly použity monoklonální protilátky (MMP-7, MMP-9, MMP-13) a E-cadherin a syndecan-1. Výsledky studie ukázaly MMP-7 a MMP-13 jako specifické markry progrese buněk SCC a potencionální cíle při léčbě karcinomu v případech recesivní dystrofické epidermalyzy bulozní. (cs)
- Background Patients with recessive dystrophic epidermolysis bullosa (RDEB) have an increased risk of developing rapidly progressive and metastatic cutaneous squamous cell carcinomas (SCC). It is unclear why these SCC behave more aggressively than sporadic SCC. Matrix metalloproteinases (MMP) are a family of endopeptidases that contribute to growth, invasion and metastasis of SCC. The role of MMP in RDEB-associated SCC is not known.Objectives To investigate the expression of MMP-7, MMP-13 and MMP-9 in RDEB-associated SCC in comparison with sporadic SCC and Bowen's disease.Methods Immunohistochemical analysis of 25 RDEB-associated SCC, 61 sporadic SCC and 28 sporadic lesions of Bowen's disease was carried out using monoclonal antibodies for MMP-7, MMP-9, MMP-13 and E-cadherin and syndecan-1.Results MMP-7 was detected in all RDEB-associated SCC, in tumour cells within the invasive edge, where E-cadherin and syndecan-1 were markedly diminished or absent. MMP-7 expression was also observed in
- Background Patients with recessive dystrophic epidermolysis bullosa (RDEB) have an increased risk of developing rapidly progressive and metastatic cutaneous squamous cell carcinomas (SCC). It is unclear why these SCC behave more aggressively than sporadic SCC. Matrix metalloproteinases (MMP) are a family of endopeptidases that contribute to growth, invasion and metastasis of SCC. The role of MMP in RDEB-associated SCC is not known.Objectives To investigate the expression of MMP-7, MMP-13 and MMP-9 in RDEB-associated SCC in comparison with sporadic SCC and Bowen's disease.Methods Immunohistochemical analysis of 25 RDEB-associated SCC, 61 sporadic SCC and 28 sporadic lesions of Bowen's disease was carried out using monoclonal antibodies for MMP-7, MMP-9, MMP-13 and E-cadherin and syndecan-1.Results MMP-7 was detected in all RDEB-associated SCC, in tumour cells within the invasive edge, where E-cadherin and syndecan-1 were markedly diminished or absent. MMP-7 expression was also observed in (en)
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| Title
| - Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas
- Exprese matrix metalloproteinas (MMP)-7 a (MMP)-13 nádorovými buňkami spinocelulárního karcinomu při epidermolysis bullosa. (cs)
- Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas (en)
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| skos:prefLabel
| - Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas
- Exprese matrix metalloproteinas (MMP)-7 a (MMP)-13 nádorovými buňkami spinocelulárního karcinomu při epidermolysis bullosa. (cs)
- Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas (en)
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| skos:notation
| - RIV/00216208:11120/08:00000811!RIV09-MSM-11120___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/08:00000811
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - metalloproteinases; squamous cell carcinoma; recessive dystrophic epidermolysis bullosa; E-cadherin; syndecan-1 (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - British Journal of Dermatology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Königová, Radana
- Kivisaari, A. K.
- Shimizu, H.
- Bauer, J. W.
- Beckert, W.
- Csikós, M.
- Kallajoki, M.
- Kähäri, V. M.
- McGrath, J. A
- Mirtti, T.
- Sato-Matsumura, K. C.
- Sawamura, D.
- Sinemus, K.
- Weber, F.
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| http://linked.open...ain/vavai/riv/wos
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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