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| rdf:type
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| Description
| - Alpha-2 adrenoceptors (alpha(2)-ARs) are critically involved in regulating neurotransmitter release from sympathetic nerves and neurons and play an important role in the regulation of awareness, arousal and vigilance. In our recent study, dexmedetomidine, a full alpha(2)-AR agonist, produced antiaggressive effects in the social conflict test in mice at doses that were twice smaller than those producing sedation. The aim of this study was to ascertain antiaggressive effect of a novel drug naphthylmedetomidine, with a more selective alpha(2)-AR activity. Behavioral effects of naphthylmedetomidine (150-1200 microg/kg i.p.) were studied in the activity cage and in the social conflict tests in mice. Naphthylmedetomidine dose dependently decreased aggressive behavior during social conflict in aggressive mice with significant reduction already at the lowest doses tested (150 microg/kg), whereas locomotion and social investigation were significantly decreased only after four times bigger dose of naphthylmedet
- Alpha-2 adrenoceptors (alpha(2)-ARs) are critically involved in regulating neurotransmitter release from sympathetic nerves and neurons and play an important role in the regulation of awareness, arousal and vigilance. In our recent study, dexmedetomidine, a full alpha(2)-AR agonist, produced antiaggressive effects in the social conflict test in mice at doses that were twice smaller than those producing sedation. The aim of this study was to ascertain antiaggressive effect of a novel drug naphthylmedetomidine, with a more selective alpha(2)-AR activity. Behavioral effects of naphthylmedetomidine (150-1200 microg/kg i.p.) were studied in the activity cage and in the social conflict tests in mice. Naphthylmedetomidine dose dependently decreased aggressive behavior during social conflict in aggressive mice with significant reduction already at the lowest doses tested (150 microg/kg), whereas locomotion and social investigation were significantly decreased only after four times bigger dose of naphthylmedet (en)
- Tato práce popisuje účinky nového alfa2-adrenergního agonisty naftylmedetomidinu u myší. Tato látka byla podávána v dávkách 150-1200 mikrog/kg i.p. u myší a její účinky sledovány pomocí aktivitní klece a testu sociálního konfliktu. Naftylmedetomidin velmi výrazně tlumil agresivitu v dávkách, které ještě nezpůsobovaly sedaci. Dalším zajímavých zjištěním bylo, že atipamezol, alfa2-adrenergní agonista, byl schopen pouze částečně antagonizovat účinky naftylmedetomidinu na sedaci. Takto vysoce selektivní antiagresivní účinek je pozorován velmi zřídka. Tato práce tak poukazuje na potenciální možnosti naftlymedetomidinu ve zvládání agresivních stavů. (cs)
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| Title
| - Selective antiaggressive effect of an alpha-2 adrenoceptor agonist naphthylmedetomidine in mice
- Selektivní antiagresivní účinek alfa2-adrenergního agonisty naftylmedetomidinu u myší (cs)
- Selective antiaggressive effect of an alpha-2 adrenoceptor agonist naphthylmedetomidine in mice (en)
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| skos:prefLabel
| - Selective antiaggressive effect of an alpha-2 adrenoceptor agonist naphthylmedetomidine in mice
- Selektivní antiagresivní účinek alfa2-adrenergního agonisty naftylmedetomidinu u myší (cs)
- Selective antiaggressive effect of an alpha-2 adrenoceptor agonist naphthylmedetomidine in mice (en)
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| skos:notation
| - RIV/00216208:11120/08:00000555!RIV09-GA0-11120___
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| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GP305/05/P003), P(NR8508), Z(MSM0021620816)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/08:00000555
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - naphthylmedetomidine; atipamezole; animal behavior; aggression; alpha-2 adrenoceptor (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Kršiak, Miloslav
- Hess, Ladislav
- Votava, Martin
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| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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