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| Description
| - The aim of the present study was to investigate whether sensitivity to flurothyl seizures after an acute methamphetamine (MA) administration is different in prenatally MA-exposed adult rats than in controls without prenatal drug exposure. Adult male and female rats exposed prenatally to MA (5mg/kg), saline or neither (controls) were divided into groups; one group received acute MA (1mg/kg s.c.) injection and the other group received saline. Rats were then challenged with flurothyl at a constant flow rate to induce seizures. The threshold of the first focal clonus, clonic seizures and tonic-clonic seizures were analyzed. EFFECTS OF PRENATAL DRUG EXPOSURE: In animals without acute MA administration prior to seizure testing, prenatal MA exposure decreased threshold of the first clonus relative to control animals. This decrease in threshold was not apparent in groups pretreated with acute MA injection.
- The aim of the present study was to investigate whether sensitivity to flurothyl seizures after an acute methamphetamine (MA) administration is different in prenatally MA-exposed adult rats than in controls without prenatal drug exposure. Adult male and female rats exposed prenatally to MA (5mg/kg), saline or neither (controls) were divided into groups; one group received acute MA (1mg/kg s.c.) injection and the other group received saline. Rats were then challenged with flurothyl at a constant flow rate to induce seizures. The threshold of the first focal clonus, clonic seizures and tonic-clonic seizures were analyzed. EFFECTS OF PRENATAL DRUG EXPOSURE: In animals without acute MA administration prior to seizure testing, prenatal MA exposure decreased threshold of the first clonus relative to control animals. This decrease in threshold was not apparent in groups pretreated with acute MA injection. (en)
- Zjišťováním citlivosti k epileptickým záchvatům po aplikaci flurothylu jsme testovali funkčnost GABA systému u dospělých samců prenatálně exponovaných metamfetaminu (MA). Všem skupinám, tedy potomkům matek s drogou i kontrolám, jsme podávali akutní aplikaci MA v dávce 1 mg/kg. Prenatální expozice MA zkracuje latenci prvního záškubu po expozici flurothylu u zvířat bez akutní aplikace MA. Toto snížení prahu pro vznik křečí nebylo patrné po aplikaci akutní dávky MA. Akutní aplikace MA (ve všech skupinách) prodlužovala latenci vzniku klonických i tonicko-klonických záchvatů. Naše výsledky ukazují, že akutní podání MA snižuje účinek prenatální aplikace MA na zvýšení pohotovosti ke křečím. Tyto výsledky svědčí pro změněnou citlivost k MA, ikdyž účinek je opačný než jsme očekávali. Výsledky byly rovněž závislé na pohlaví a estrálním cyklu samic. (cs)
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| Title
| - Does prenatal methamphetamine exposure affect seizure susceptibility in adult rats with acute administration of the same drug?
- Ovlivňuje prenatální expozice metamfetaminu záchvatovou pohotovost laboratorních pokanů po aplikaci stejné drogy v dospělosti? (cs)
- Does prenatal methamphetamine exposure affect seizure susceptibility in adult rats with acute administration of the same drug? (en)
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| skos:prefLabel
| - Does prenatal methamphetamine exposure affect seizure susceptibility in adult rats with acute administration of the same drug?
- Ovlivňuje prenatální expozice metamfetaminu záchvatovou pohotovost laboratorních pokanů po aplikaci stejné drogy v dospělosti? (cs)
- Does prenatal methamphetamine exposure affect seizure susceptibility in adult rats with acute administration of the same drug? (en)
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| skos:notation
| - RIV/00216208:11120/08:00000550!RIV09-GA0-11120___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(1M0517), P(GA305/06/0283), Z(MSM0021620816)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/08:00000550
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - methamphetamine; flurothyl; seizures; gender; estrous cycle (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Schutová, Barbora
- Šlamberová, Romana
- Bernášková, Klára
- Matějovská, Iveta
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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