About: Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone

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About: Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.cyto.2007.06.001
Description	The aim of this study was to investigate the expression of several cytokines, matrix metalloproteinases (MMPs), and tissue inhibitor of matrix metalloproteinases (TIMP)-1 in osteoarthritis (OA) and control sera and different joint tissues. Serum, synovial fluid, cartilage, synovial and subchondral bone tissues were examined in OA and control subjects. The protein level of tumor necrosis factor (TNF)-alpha, interleukin (IL)-lot, IL-8, IL-10 and MMP-2, MMP-3, MMPP-9, and TIMP-1 were measured by immunoanalysis. Serum levels of TNF-alpha, MMP-3 and -9 were significantly higher in OA patients than in controls. Conversely, serum IL-10 was decreased in OA patients. CRP was elevated when compared to healthy controls and decreased significantly 6 months after the surgery. The aim of this study was to investigate the expression of several cytokines, matrix metalloproteinases (MMPs), and tissue inhibitor of matrix metalloproteinases (TIMP)-1 in osteoarthritis (OA) and control sera and different joint tissues. Serum, synovial fluid, cartilage, synovial and subchondral bone tissues were examined in OA and control subjects. The protein level of tumor necrosis factor (TNF)-alpha, interleukin (IL)-lot, IL-8, IL-10 and MMP-2, MMP-3, MMPP-9, and TIMP-1 were measured by immunoanalysis. Serum levels of TNF-alpha, MMP-3 and -9 were significantly higher in OA patients than in controls. Conversely, serum IL-10 was decreased in OA patients. CRP was elevated when compared to healthy controls and decreased significantly 6 months after the surgery. (en)
Title	Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone (en)
skos:prefLabel	Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone (en)
skos:notation	RIV/00216208:11120/07:00003122!RIV12-MZ0-11120___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR7907)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Klézl, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	425946
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/07:00003122
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ostcoarthritis; cytokines; metalloproteinases; inflammation (en)
http://linked.open.../riv/klicoveSlovo	ostcoarthritis metalloproteinases inflammation cytokines
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B07E02B7469F]
http://linked.open...i/riv/nazevZdroje	Cytokine
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Apoptosis in osteoarthritis: Investigation of the expression of apoptosi modulating molecules and the presence of cell death in OA joint tissues.
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	38
http://linked.open...iv/tvurceVysledku	Klézl, Zdeněk Hulejová, Hana
http://linked.open...ain/vavai/riv/wos	000249474300006
issn	1043-4666
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.cyto.2007.06.001
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone

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