| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Cílem této studie bylo ukázat odlišný účinek pre a postsynaptických serotoninových-1A (5-HT1A) receptorů na psychóze podobné chování způsobené podáním antagonisty NMDA receptoru, dizocilpinu (MK-801). Samci potkana kmene Wistar obdrželi dvě dávky (0.025 mg/kg a 1 mg/kg) agonisty 5-HT1A receptoru 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) a MK-801 (0,1 mg/kg a 0,3 mg/kg). Měřili jsme zpracování sensorimotorických informací pomocí testu prepulzní inhibice úlekové reakce (PPI) a lokomoční aktivitu potkanů. Našli jsme odlišný účinek nízké a vysoké dávky 5-HT1A agonisty na deficit v PPI a hyperlokomoci u habituovaných potkanů způsobené MK-801. Nízká dávka 8-OH-DPAT, která aktivuje přednostně presynaptické 5-HT1A receptory, zlepšila deficit v PPI a hyperlokomoci u habituovaných potkanů po podání MK-801 (0.1 mg/kg). Nicméně, vysoká dávka 8-OH-DPAT, která aktivuje oba pre- i postsynaptické 5-HT1A receptory, snížila PPI a zvýšila lokomoční aktivitu po podání nízké dávky MK-801. Podání 8-OH-DPAT samotné (cs)
- The purpose of the present study was to investigate the opposite effect of the pre- and postsynaptic serotonin-1A (5-HT1A) receptors on the psychotic-like behavior induced by a non-competitive antagonist of the NMDA receptor, dizocilpine (MK-801). Male Wistar rats received two doses (0.025 mg/kg and 1 mg/kg) of 5-HT1A receptor agonist 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino) tetralin) and/or MK-801 in two different doses, 0.1 mg/kg or 0.3 mg/kg. We measured sensorimotor gating by testing prepulse inhibition of acoustic startle response (PPI) and locomotor activity of rats. We found an opposite effect of the low and high 5-HT1A receptor agonist doses on MK-801 induced deficit in PPI and hyperlocomotion in habituated rats. The low dose of 8-OH-DPAT, which preferentially acts on presynaptic 5-HT1A receptors, restored the deficit in PPI and hyperlocomotion in MK-801 (0.1 mg/kg)-treated habituated rats. However, the high dose of 8-OH-DPAT, which activates both pre- and postsynaptic 5-HT1A receptors, decre
- The purpose of the present study was to investigate the opposite effect of the pre- and postsynaptic serotonin-1A (5-HT1A) receptors on the psychotic-like behavior induced by a non-competitive antagonist of the NMDA receptor, dizocilpine (MK-801). Male Wistar rats received two doses (0.025 mg/kg and 1 mg/kg) of 5-HT1A receptor agonist 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino) tetralin) and/or MK-801 in two different doses, 0.1 mg/kg or 0.3 mg/kg. We measured sensorimotor gating by testing prepulse inhibition of acoustic startle response (PPI) and locomotor activity of rats. We found an opposite effect of the low and high 5-HT1A receptor agonist doses on MK-801 induced deficit in PPI and hyperlocomotion in habituated rats. The low dose of 8-OH-DPAT, which preferentially acts on presynaptic 5-HT1A receptors, restored the deficit in PPI and hyperlocomotion in MK-801 (0.1 mg/kg)-treated habituated rats. However, the high dose of 8-OH-DPAT, which activates both pre- and postsynaptic 5-HT1A receptors, decre (en)
|
| Title
| - The opposite effect of a low and a high dose of serotonin-1A agonist on behavior induced by MK-801
- Opačný účinek nízké a vysoké dávky agonisty serotoninových-1A receptorů na chování indukované MK-801 (cs)
- The opposite effect of a low and a high dose of serotonin-1A agonist on behavior induced by MK-801 (en)
|
| skos:prefLabel
| - The opposite effect of a low and a high dose of serotonin-1A agonist on behavior induced by MK-801
- Opačný účinek nízké a vysoké dávky agonisty serotoninových-1A receptorů na chování indukované MK-801 (cs)
- The opposite effect of a low and a high dose of serotonin-1A agonist on behavior induced by MK-801 (en)
|
| skos:notation
| - RIV/00216208:11120/07:00000317!RIV08-MSM-11120___
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(1M0517), P(NL7684), Z(MSM0021620816)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/07:00000317
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - serotonin 5-HT1A receptors; 8-OH-DPAT; MK-801; PPI; locomotor activity; rats; schizophrenia (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Horáček, Jiří
- Páleníček, Tomáš
- Bubeníková-Valešová, Věra
- Votava, Martin
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| http://localhost/t...ganizacniJednotka
| |
| is http://linked.open...avai/riv/vysledek
of | |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)