About: Expression and production of spinal cyclooxygenase 1 and 2 in the model of experimental osteoarthritis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Práce popisuje problematiku exprese a produkce spinální cyklooxygenázy 1 a 2 v modelu experimentální osteoartritídy (cs) Osteoarthritis (OA) is a degenerative joint disease.Th ejoints are characterized by a progressive degeneration of articular cartilage leading to inflammattion and pain.In attempt to study the pathophysiology of OA, numerous experimental model that mimic human OA have been developed.Chemical models of OA involve intraarticular injection of chemical compounds that can have a number of effects on joint physiology.Surgical models of OA induce joint instability by partial menisectomy.One of the most frequently used model is the model of monoiodoacetate (MIA) induced OA.Local injection of monoiodoacetate, an inhibitor of glycolysis,disrupt chondrocyte metabolism and produces cartilage degeneration.In mice,injection of monoiodoacetate led to strong inhibition of proteoglycan synthesis in the patella and in the medial part of tibial plateau.The loss of locomotor activity and the severity of cartilage lesions in patella were observed in rats injected with MIA.It was previously described, the important role of Osteoarthritis (OA) is a degenerative joint disease.Th ejoints are characterized by a progressive degeneration of articular cartilage leading to inflammattion and pain.In attempt to study the pathophysiology of OA, numerous experimental model that mimic human OA have been developed.Chemical models of OA involve intraarticular injection of chemical compounds that can have a number of effects on joint physiology.Surgical models of OA induce joint instability by partial menisectomy.One of the most frequently used model is the model of monoiodoacetate (MIA) induced OA.Local injection of monoiodoacetate, an inhibitor of glycolysis,disrupt chondrocyte metabolism and produces cartilage degeneration.In mice,injection of monoiodoacetate led to strong inhibition of proteoglycan synthesis in the patella and in the medial part of tibial plateau.The loss of locomotor activity and the severity of cartilage lesions in patella were observed in rats injected with MIA.It was previously described, the important role of (en)
Title	Expression and production of spinal cyclooxygenase 1 and 2 in the model of experimental osteoarthritis Exprese a produkce spinální cyklooxygenázy 1 a 2 v modelu experimentální osteoartritídy (cs) Expression and production of spinal cyclooxygenase 1 and 2 in the model of experimental osteoarthritis (en)
skos:prefLabel	Expression and production of spinal cyclooxygenase 1 and 2 in the model of experimental osteoarthritis Exprese a produkce spinální cyklooxygenázy 1 a 2 v modelu experimentální osteoartritídy (cs) Expression and production of spinal cyclooxygenase 1 and 2 in the model of experimental osteoarthritis (en)
skos:notation	RIV/00216208:11120/07:00000303!RIV08-MSM-11120___
http://linked.open.../vavai/riv/strany	73-74
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR9072), Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika	Suppl. 1
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Procházková, Michaela Kršiak, Miloslav Doležal, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	421403
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/07:00000303
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	osteoarthritis; cyclooxygenase; spinal cord; pain (en)
http://linked.open.../riv/klicoveSlovo	osteoarthritis pain spinal cord cyclooxygenase
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[B22EF0BB67D0]
http://linked.open...i/riv/nazevZdroje	Biomedical Papers
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of neurotransmitters in mechanism of action of non-opioid analgesics
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	151
http://linked.open...iv/tvurceVysledku	Kršiak, Miloslav Doležal, Tomáš Zanvit, P. Procházková, Michaela Prokešová, L.
http://linked.open...n/vavai/riv/zamer	Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace
issn	1213-8118
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Expression and production of spinal cyclooxygenase 1 and 2 in the model of experimental osteoarthritis Expression and production of spinal cyclooxygenase 1 and 2 in the model of experimental osteoarthritis Expression and production of spinal cyclooxygenase 1 and 2 in the model of experimental osteoarthritis

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