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| rdf:type
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| Description
| - Increased numbers of rosettes of podosomes were observed in overgrown rat Rous sarcoma RsK4 cells. A possible role of these structures in nutrient uptake in tumour cell survival was investigated by exposure to acute starvation. A single cell suspension of RsK4 cells in Hanks balanced salt solution was allowed to interact with either clean uncoated or serum-coated for bait coverglasses. Confocal microscopy revealed contrasting 3D cell morphologies that were associated with conspicuous patterns of podosomal structures, which on the coated coverglasses resembled the sealing zones of osteoclasts, while on the uncoated coverglasses they resembled the marginal podosomes of migrating monocyte-derived cells. Thus, the arising podosomal structures, the involvement of which in an uptake of nutrients appeared feasible morphologically, were associated with the emerging 3D cell shapes guided by the microenvironment. Such phenotypic plasticity of neoplastic RsK4 cells in response to micro-environmental challenge su
- Increased numbers of rosettes of podosomes were observed in overgrown rat Rous sarcoma RsK4 cells. A possible role of these structures in nutrient uptake in tumour cell survival was investigated by exposure to acute starvation. A single cell suspension of RsK4 cells in Hanks balanced salt solution was allowed to interact with either clean uncoated or serum-coated for bait coverglasses. Confocal microscopy revealed contrasting 3D cell morphologies that were associated with conspicuous patterns of podosomal structures, which on the coated coverglasses resembled the sealing zones of osteoclasts, while on the uncoated coverglasses they resembled the marginal podosomes of migrating monocyte-derived cells. Thus, the arising podosomal structures, the involvement of which in an uptake of nutrients appeared feasible morphologically, were associated with the emerging 3D cell shapes guided by the microenvironment. Such phenotypic plasticity of neoplastic RsK4 cells in response to micro-environmental challenge su (en)
- Rozety podosomů byly pozorovány u přerostlých RsK4 buněk. To vzbudilo zájem o možnou úlohu podosomů v příjmu živin do buňky. Vyšetření dynamiky podosomů konfokálním mikroskopem ukázalo, že vyhladovělé sarkomové buňky RsK4 nasazené v HBSS na čistá anebo sérovými proteiny pokrytá krycí sklíčka reagují na tyto podmínky mikroprostředí odlišně. Čistá sklíčka indukovala morfotyp a podosomy podobné migrujícím monocytům, zatímco proteinový povlak vyvolal morfotyp a podosomy analogické osteoklastům. Tato fenotypická plasticita jako odpověd na mikroenvironmentální podmínky naznačila, že může být významným příznakem malignity. (cs)
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| Title
| - Arising podosomal structures are associated with neoplastic cell morphological phenotype induced by the microenvironment
- Arising podosomal structures are associated with neoplastic cell morphological phenotype induced by the microenvironment (en)
- Vznikající podosomální struktury souvisí s morfologickým fenotypem neoplastické buňky, který je indukován mikroprostředím (cs)
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| skos:prefLabel
| - Arising podosomal structures are associated with neoplastic cell morphological phenotype induced by the microenvironment
- Arising podosomal structures are associated with neoplastic cell morphological phenotype induced by the microenvironment (en)
- Vznikající podosomální struktury souvisí s morfologickým fenotypem neoplastické buňky, který je indukován mikroprostředím (cs)
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| skos:notation
| - RIV/00216208:11120/06:00000535!RIV09-MZ0-11120___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(NR8145), Z(AV0Z50520514)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/06:00000535
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - podosomes; rat Rous sarcoma cells; neoplastic cell morphotype; acute starvation; microenvironment; phenotypic plasticity (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Veselý, Pavel
- Matoušková, Eva
- Bereiter-Hahn, J.
- Blase, C.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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