About: Syngeneic lymph-node-targeting model of green fluorescent protein-expressing Lewis lung carcinoma

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About: Syngeneic lymph-node-targeting model of green fluorescent protein-expressing Lewis lung carcinoma Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The Lewis lung tumor has been extensively studied in both syngeneic and allogeneic mouse models. However, its metastatic potential and mechanism are poorly understood. The aim of the present study was to develop a highly metastatic lymph-node targeting, imageable model of the Lewis lung carcinoma in a syngeneic host. We report here a syngeneic model of the Lewis lung carcinoma in which the carcinoma cells are labeled with green fluorescent protein (GFP). The tumor cells were transplanted in the dorsal side of the ear of C57-B16 mice in order to give the tumor cells access to the lymphatic system. This model of the Lewis lung carcinoma extensively metastasized to numerous lymph nodes throughout the body of the animal as well as visceral organs, as visualized by fluorescence microscopy using the bright GFP signal. Twenty-one different metastatic sites, including lymph nodes throughout the body, were identified among the cohort of transplanted animals. The data demonstrate a predilection of the Lewis lun The Lewis lung tumor has been extensively studied in both syngeneic and allogeneic mouse models. However, its metastatic potential and mechanism are poorly understood. The aim of the present study was to develop a highly metastatic lymph-node targeting, imageable model of the Lewis lung carcinoma in a syngeneic host. We report here a syngeneic model of the Lewis lung carcinoma in which the carcinoma cells are labeled with green fluorescent protein (GFP). The tumor cells were transplanted in the dorsal side of the ear of C57-B16 mice in order to give the tumor cells access to the lymphatic system. This model of the Lewis lung carcinoma extensively metastasized to numerous lymph nodes throughout the body of the animal as well as visceral organs, as visualized by fluorescence microscopy using the bright GFP signal. Twenty-one different metastatic sites, including lymph nodes throughout the body, were identified among the cohort of transplanted animals. The data demonstrate a predilection of the Lewis lun (en) Práce popisuje syngeneický lymph-node-targeting model zeleného fluorescentního protein-expresující Lewisův plicní karcinom (cs)
Title	Syngeneic lymph-node-targeting model of green fluorescent protein-expressing Lewis lung carcinoma Syngeneic lymph-node-targeting model of green fluorescent protein-expressing Lewis lung carcinoma (en) Syngeneický lymph-node-targeting model zeleného fluorescentního protein-expresující Lewisův plicní karcinom (cs)
skos:prefLabel	Syngeneic lymph-node-targeting model of green fluorescent protein-expressing Lewis lung carcinoma Syngeneic lymph-node-targeting model of green fluorescent protein-expressing Lewis lung carcinoma (en) Syngeneický lymph-node-targeting model zeleného fluorescentního protein-expresující Lewisův plicní karcinom (cs)
skos:notation	RIV/00216208:11120/04:00000954!RIV09-MSM-11120___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Pintérová, Daniela Bobek, Vladimír Kološtová, Katarína Boubelík, Michael
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	589279
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/04:00000954
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	metastasis; growth; cells; mice; implantation; cancer; mouse; host (en)
http://linked.open.../riv/klicoveSlovo	host cancer growth metastasis cells mice implantation mouse
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[C7BB9E57CEA7]
http://linked.open...i/riv/nazevZdroje	Clinical & Experimental Metastasis
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Bobek, Vladimír Kološtová, Katarína Pintérová, Daniela Yang, M. Boubelík, Michael Jiang, P. Hoffman, R. M.
http://linked.open...ain/vavai/riv/wos	000229240600004
issn	0262-0898
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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