About: Pharmacogenetics and mood stabilization in bipolar disorder

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1002/ajmg.c.20010
Description	Bipolar disorder is a severe psychiatric disease characterized by varying treatment response among individual patients. Effects of certain treatments, for instance, lithium, can be predicted from clinical characteristics of patients and their family histories. This led to a suggestion that a treatment response could identify subtypes of bipolar disorder particularly suited for gene-mapping studies. In this paper we review family and molecular studies of bipolar disorder responsive to lithium, as well as studies aiming to identify polymorphisms associated with the treatment response itself. While molecular genetic research and gene expression studies promise to bring new insights into the pathophysiology of the illness and the nature of treatment response, and thus provide new information for better treatment of bipolar disorder in the future, results from family studies and studies of clinical correlates of treatment response may already be utilized in the management of bipolar disorder Bipolar disorder is a severe psychiatric disease characterized by varying treatment response among individual patients. Effects of certain treatments, for instance, lithium, can be predicted from clinical characteristics of patients and their family histories. This led to a suggestion that a treatment response could identify subtypes of bipolar disorder particularly suited for gene-mapping studies. In this paper we review family and molecular studies of bipolar disorder responsive to lithium, as well as studies aiming to identify polymorphisms associated with the treatment response itself. While molecular genetic research and gene expression studies promise to bring new insights into the pathophysiology of the illness and the nature of treatment response, and thus provide new information for better treatment of bipolar disorder in the future, results from family studies and studies of clinical correlates of treatment response may already be utilized in the management of bipolar disorder (en)
Title	Pharmacogenetics and mood stabilization in bipolar disorder Pharmacogenetics and mood stabilization in bipolar disorder (en)
skos:prefLabel	Pharmacogenetics and mood stabilization in bipolar disorder Pharmacogenetics and mood stabilization in bipolar disorder (en)
skos:notation	RIV/00216208:11120/03:00003862!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM 111200005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Růžičková, Martina Alda, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	620745
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/03:00003862
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	pharmacogenetics; bipolar disorder; lithium; treatment response (en)
http://linked.open.../riv/klicoveSlovo	lithium treatment response pharmacogenetics bipolar disorder
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[ECC322E50A46]
http://linked.open...i/riv/nazevZdroje	American Journal of Medical Genetics Part C-Seminars in Medical Genetics
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	123C
http://linked.open...iv/tvurceVysledku	Alda, Martin Růžičková, Martina
http://linked.open...ain/vavai/riv/wos	000186309000003
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111200005
issn	0148-7299
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/ajmg.c.20010
http://localhost/t...ganizacniJednotka	11120

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