About: Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice

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About: Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1128/Iai.71.4.2041-2046.2003
Description	The mouse strains BALB/cHeA (BALB/c) and STS/A (STS) are susceptible and resistant to Leishmania major-induced disease, respectively. We analyzed this difference using recombinant congenic (RC) BALB/c-c-STS/Dem (CcS/Dem) strains that carry different random subsets of 12.5% genes of the strain STS in a BALB/c background. Previously, testing the resistant strain CcS-5, we found five novel Lmr (Leishmania major response) loci, each associated with a different combination of pathological and immunological reactions. Here we analyze the response of RC strain CcS-16, which is even more susceptible to L. major than BALB/c. In the (CcS-16 x BALB/c)F-2 hybrids we mapped three novel loci that influence cutaneous or visceral pathology. Lmr14 (chromosome 2) controls splenomegaly and hepatomegaly. On the other hand Lmr15 (chromosome 11) determines hepatomegaly only, and Lmr13 (chromosome 18) determines skin lesions only. These data confirm the complex control of L. major-induced pathology, where cutaneous and visc The mouse strains BALB/cHeA (BALB/c) and STS/A (STS) are susceptible and resistant to Leishmania major-induced disease, respectively. We analyzed this difference using recombinant congenic (RC) BALB/c-c-STS/Dem (CcS/Dem) strains that carry different random subsets of 12.5% genes of the strain STS in a BALB/c background. Previously, testing the resistant strain CcS-5, we found five novel Lmr (Leishmania major response) loci, each associated with a different combination of pathological and immunological reactions. Here we analyze the response of RC strain CcS-16, which is even more susceptible to L. major than BALB/c. In the (CcS-16 x BALB/c)F-2 hybrids we mapped three novel loci that influence cutaneous or visceral pathology. Lmr14 (chromosome 2) controls splenomegaly and hepatomegaly. On the other hand Lmr15 (chromosome 11) determines hepatomegaly only, and Lmr13 (chromosome 18) determines skin lesions only. These data confirm the complex control of L. major-induced pathology, where cutaneous and visc (en)
Title	Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice (en)
skos:prefLabel	Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice (en)
skos:notation	RIV/00216208:11120/03:00003831!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA310/00/0760), P(GA310/03/1381), P(OK 394), S, Z(AV0Z5052915), Z(MSM 113100004)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Lipoldová, Marie Badalová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	603840
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/03:00003831
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	recombinant congenic strains; multiple loci; nitric-oxide; susceptibility; linkage; heterogeneity; resistance; immunity; 5Q31-Q33; traits (en)
http://linked.open.../riv/klicoveSlovo	nitric-oxide resistance susceptibility linkage recombinant congenic strains heterogeneity immunity 5Q31-Q33 multiple loci traits
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[0040475956F1]
http://linked.open...i/riv/nazevZdroje	Infection and Immunity
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetic analysis of immune response Genetic analysis of immune response II. http://linked.opendata.cz/resource/domain/vavai/projekt/OK%20394
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	71
http://linked.open...iv/tvurceVysledku	Lipoldová, Marie Badalová, Jana
http://linked.open...ain/vavai/riv/wos	000181926200053
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20113100004
issn	0019-9567
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1128/Iai.71.4.2041-2046.2003
http://localhost/t...ganizacniJednotka	11120

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