About: Short bursts of weak pulses break postictal inhibition in the neocortex of Wistar rats

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About: Short bursts of weak pulses break postictal inhibition in the neocortex of Wistar rats Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1046/j.1528-1157.2003.42702.x
Description	Postictal inhibition (PI) is a decrease in excitability that follows an epileptic seizure and decreases probability of new seizure occurrence. PI may involve both increased inhibition and persisting elevated excitation. Our experiments tested whether shorter trains of weak stimuli are able to unmask this residual increase of excitability during the PI. Four epileptic afterdischarges (ADs) were evoked by intense electrical stimulation (20 s, 8 Hz, current intensity at 5x threshold) of the neocortex in two groups (A, B) of Wistar rats. Before the first AD and during the 10-min interictal period, 8-Hz trains of four weak pulses (half of the intensity used for the AD triggering; 4P) were applied every 20 s in group B and a single pulse with similar parameters in group A. The number of interictal epileptiform events evoked by 4P in the group B was significantly higher than that in the group A (evoked by single pulses) except after the second AD. Epileptic events were triggered by 4P also immediately after Postictal inhibition (PI) is a decrease in excitability that follows an epileptic seizure and decreases probability of new seizure occurrence. PI may involve both increased inhibition and persisting elevated excitation. Our experiments tested whether shorter trains of weak stimuli are able to unmask this residual increase of excitability during the PI. Four epileptic afterdischarges (ADs) were evoked by intense electrical stimulation (20 s, 8 Hz, current intensity at 5x threshold) of the neocortex in two groups (A, B) of Wistar rats. Before the first AD and during the 10-min interictal period, 8-Hz trains of four weak pulses (half of the intensity used for the AD triggering; 4P) were applied every 20 s in group B and a single pulse with similar parameters in group A. The number of interictal epileptiform events evoked by 4P in the group B was significantly higher than that in the group A (evoked by single pulses) except after the second AD. Epileptic events were triggered by 4P also immediately after (en)
Title	Short bursts of weak pulses break postictal inhibition in the neocortex of Wistar rats Short bursts of weak pulses break postictal inhibition in the neocortex of Wistar rats (en)
skos:prefLabel	Short bursts of weak pulses break postictal inhibition in the neocortex of Wistar rats Short bursts of weak pulses break postictal inhibition in the neocortex of Wistar rats (en)
skos:notation	RIV/00216208:11120/03:00003038!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM 111200005)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Lambert, Lukáš Krýsl, David Mareš, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	626913
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/03:00003038
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Epilepsy; Postictal inhibition; electrical stimulation; Rat; Kindling; Seizure (en)
http://linked.open.../riv/klicoveSlovo	Epilepsy Rat Seizure electrical stimulation Kindling Postictal inhibition
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B2C1487F9F70]
http://linked.open...i/riv/nazevZdroje	Epilepsia
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	44
http://linked.open...iv/tvurceVysledku	Krýsl, David Mareš, Jan Tůma, Lukáš
http://linked.open...ain/vavai/riv/wos	000182732400002
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111200005
issn	0013-9580
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1046/j.1528-1157.2003.42702.x
http://localhost/t...ganizacniJednotka	11120

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