About: Antimutagenic Effect of Ellagic Acid and its Effect on the Immune Response in Mice

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Using the Ames bacterial mutagenicity test and an in vivo micronucleus test, we investigated the antigenotoxic effect of ellagic acid (EA) against the genotoxicity of three mutagens: aminomethylimidazo-quinoline (IQ), aflatoxin B1 (AFB1), and N-nitroso-N-methylurea (MNU). Ellagic acid is naturally occuring phenolic compound which is found in a variety of soft fruits and vegetables. Effect of this compound on immunosupressive activity of mutagens was followed in vivo by the chemiluminiscence test. In the Ames assay, ellagic acid at concentrations of 300 and 30 g/plate demonstrably inhibits the mutagenic activity of two indirect mutagens: IQ and AFB1. The concentration of 300 g per plate had the strongest effect on mutagenicity of all concentrations of IQ in strain TA 98 of Salmonella typhimurium whereas in strain TA 100, it was 30 g per dish of ellagic acid that was more effective than 300 g/plate. Also in combination with different concentrations of AFB1 ellagic acid was proved to be a strong antimuta Using the Ames bacterial mutagenicity test and an in vivo micronucleus test, we investigated the antigenotoxic effect of ellagic acid (EA) against the genotoxicity of three mutagens: aminomethylimidazo-quinoline (IQ), aflatoxin B1 (AFB1), and N-nitroso-N-methylurea (MNU). Ellagic acid is naturally occuring phenolic compound which is found in a variety of soft fruits and vegetables. Effect of this compound on immunosupressive activity of mutagens was followed in vivo by the chemiluminiscence test. In the Ames assay, ellagic acid at concentrations of 300 and 30 g/plate demonstrably inhibits the mutagenic activity of two indirect mutagens: IQ and AFB1. The concentration of 300 g per plate had the strongest effect on mutagenicity of all concentrations of IQ in strain TA 98 of Salmonella typhimurium whereas in strain TA 100, it was 30 g per dish of ellagic acid that was more effective than 300 g/plate. Also in combination with different concentrations of AFB1 ellagic acid was proved to be a strong antimuta (en)
Title	Antimutagenic Effect of Ellagic Acid and its Effect on the Immune Response in Mice Antimutagenic Effect of Ellagic Acid and its Effect on the Immune Response in Mice (en)
skos:prefLabel	Antimutagenic Effect of Ellagic Acid and its Effect on the Immune Response in Mice Antimutagenic Effect of Ellagic Acid and its Effect on the Immune Response in Mice (en)
skos:notation	RIV/00216208:11120/02:00011166!RIV/2003/MZ0/111203/N
http://linked.open.../vavai/riv/strany	181;191
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NJ6138), Z(MSM 111200001)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Šmerák, Petr Polívková, Zdeňka Turek, Bohumil Anděl, M. Bártová, Jiřina Bárta, Ivo Langová, Martina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	638561
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/02:00011166
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Antimutagenic;Effect;Ellagic;Effect;Immune;Response;Mice (en)
http://linked.open.../riv/klicoveSlovo	Response Mice Effect Antimutagenic Ellagic Immune
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[50CC245FE39D]
http://linked.open...i/riv/nazevZdroje	Czech Journal of Food Sciences
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of antimutagenic effect and immunomodulatory activity of natural substances
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Anděl, Michal Bártová, Jiřina Turek, Bohumil Bárta, Ivo Polívková, Zdeňka Šmerák, Petr Langová, Martina
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111200001
issn	1212-1800
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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