About: Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9

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About: Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9 Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1053/gast.2002.37052
Description	Carbonic anhydrase (CA) IX is a highly active enzyme with adhesion capacity that is functionally implicated in acid-base balance and intercellular communication. It is normally present in basolateral membranes of gastrointestinal epithelial cells and ectopically expressed in various carcinomas. To show its physiologic relevance, we have cloned the Car9 gene and generated CA IX-deficient mice. The mice with null mutation of the Car9 gene were obtained by targeted gene disruption. Tissue architecture and expression of markers were determined by histochemical and immunohistochemical techniques. Mice homozygous for the mutation developed gastric hyperplasia of the glandular epithelium with numerous cysts. The first changes were observed in the newborn animals, and the hyperplasia became prominent at the end of gastric morphogenesis in 4-week-old mice. Loss of CA IX led to overproduction of mucus-secreting pit cells and depletion of pepsinogen-positive chief cells. The proportion of H+/K+-adenosine triphos Carbonic anhydrase (CA) IX is a highly active enzyme with adhesion capacity that is functionally implicated in acid-base balance and intercellular communication. It is normally present in basolateral membranes of gastrointestinal epithelial cells and ectopically expressed in various carcinomas. To show its physiologic relevance, we have cloned the Car9 gene and generated CA IX-deficient mice. The mice with null mutation of the Car9 gene were obtained by targeted gene disruption. Tissue architecture and expression of markers were determined by histochemical and immunohistochemical techniques. Mice homozygous for the mutation developed gastric hyperplasia of the glandular epithelium with numerous cysts. The first changes were observed in the newborn animals, and the hyperplasia became prominent at the end of gastric morphogenesis in 4-week-old mice. Loss of CA IX led to overproduction of mucus-secreting pit cells and depletion of pepsinogen-positive chief cells. The proportion of H+/K+-adenosine triphos (en)
Title	Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9 Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9 (en)
skos:prefLabel	Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9 Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9 (en)
skos:notation	RIV/00216208:11120/02:00003811!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	N P Z
http://linked.open...avai/riv/aktivity	N, P(GV312/96/K205), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vernerová, Zdeňka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	646826
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/02:00003811
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Transcription Factor Fkh6; Parietal-Cells; Mn/Ca-Ix; Gastrointestinal-Tract; Mn Antigen; Expression; Lacking; Protein; Domain; Differentiation (en)
http://linked.open.../riv/klicoveSlovo	Expression Gastrointestinal-Tract Domain Protein Differentiation Lacking Mn Antigen Mn/Ca-Ix Parietal-Cells Transcription Factor Fkh6
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E5851184017C]
http://linked.open...i/riv/nazevZdroje	Gastroenterology
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...vavai/riv/projekt	Gene src and related src family protein tyrosine kinases (PTK) involvement in cell signalling and differentiation and their pathogenic and oncogenic activities
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	123
http://linked.open...iv/tvurceVysledku	Vernerová, Zdeňka Gut, M. O.
http://linked.open...ain/vavai/riv/wos	000179545300020
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	0016-5085
number of pages	15 (xsd:int)
http://bibframe.org/vocab/doi	10.1053/gast.2002.37052
http://localhost/t...ganizacniJednotka	11120

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