About: Analysis of binding of mannosides in relation to Langerin (CD207) in Langerhans cells of normal and transformed epithelia

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About: Analysis of binding of mannosides in relation to Langerin (CD207) in Langerhans cells of normal and transformed epithelia Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1023/A:1021793530802
Description	Tandem-repeat C-type lectins (pattern-recognition receptors) with specificity for mannosides are intimately involved in antigen recognition, uptake, routing and presentation in macrophages and dendritic cells. In Langerhans cells, Langerin (CD207), a type-II transmembrane protein with a single C-type carbohydrate recognition domain attached to a heptad repeat in the neck region, which is likely to establish oligomers with an alpha-coiled-coil stalk, has been implicated in endocytosis and the formation of Birbeck granules. The structure of Langerin harbours essential motifs for Ca2+-binding and sugar accommodation. Lectin activity has previously been inferred by diminished antibody binding to cells in the presence of the glycan ligand mannan. In view of the complexity of the C-type lectin/lectin-like network, it is unclear what role Langerin plays for Langerhans cells in binding mannosides. Tandem-repeat C-type lectins (pattern-recognition receptors) with specificity for mannosides are intimately involved in antigen recognition, uptake, routing and presentation in macrophages and dendritic cells. In Langerhans cells, Langerin (CD207), a type-II transmembrane protein with a single C-type carbohydrate recognition domain attached to a heptad repeat in the neck region, which is likely to establish oligomers with an alpha-coiled-coil stalk, has been implicated in endocytosis and the formation of Birbeck granules. The structure of Langerin harbours essential motifs for Ca2+-binding and sugar accommodation. Lectin activity has previously been inferred by diminished antibody binding to cells in the presence of the glycan ligand mannan. In view of the complexity of the C-type lectin/lectin-like network, it is unclear what role Langerin plays for Langerhans cells in binding mannosides. (en)
Title	Analysis of binding of mannosides in relation to Langerin (CD207) in Langerhans cells of normal and transformed epithelia Analysis of binding of mannosides in relation to Langerin (CD207) in Langerhans cells of normal and transformed epithelia (en)
skos:prefLabel	Analysis of binding of mannosides in relation to Langerin (CD207) in Langerhans cells of normal and transformed epithelia Analysis of binding of mannosides in relation to Langerin (CD207) in Langerhans cells of normal and transformed epithelia (en)
skos:notation	RIV/00216208:11120/02:00003605!RIV12-GA0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA304/02/0463), P(LN00A065), Z(MSM 111100005)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Dvořánková, Barbora
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	638046
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/02:00003605
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Human Dendritic Cells; Endogenous Lectins; Birbeck Granules; Animal Lectins; Schwann-Cells; Receptor; Surface; Antigen; Immunohistochemistry; Expression (en)
http://linked.open.../riv/klicoveSlovo	Surface Expression Receptor Antigen Animal Lectins Birbeck Granules Endogenous Lectins Human Dendritic Cells Schwann-Cells Immunohistochemistry
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[ED4A38F682F4]
http://linked.open...i/riv/nazevZdroje	Histochemical Journal
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Cell Therapy and Tissue Repair Functions of galectins (-1, -3, -7) in head and neck squamous cell carcinomas
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	34
http://linked.open...iv/tvurceVysledku	Dvořánková, Barbora Plzák, J.
http://linked.open...ain/vavai/riv/wos	000179944100006
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111100005
issn	0018-2214
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1023/A:1021793530802
http://localhost/t...ganizacniJednotka	11120

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