About: Hippocampal Damage Mediated by Corticosteroids a Neuropsychiatric Research Challenge

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1007/BF03035134
Description	There is an increasing evidence that corticosteroids damage the hippocampus in rodents and in primates. Hippocampal atrophy induced by corticosteroids may play an important role in the pathogenesis of a range of neuropsychiatric disorders. Hippocampus is necessary for short-term memory consolidation and HPA axis regulation. Signs of hippocampal damage (HPA dysregulation in combination with memory impairment) are found in affective disorders, Alzheimer's disease and in posttraumatic stress disorder. MRI volumetry reveals reduced hippocampal volume in these diseases. Evidence supporting the %22glucocorticoid hypothesis%22 of psychiatric disorders is reviewed in the first part of the paper. Unresolved questions concerning temporary aspects of neurodegeneration, causality, reversibility, type of damage, factors increasing hippocampal vulnerability, and both pharmacological (CRH antagonists, antiglucocorticoid drugs, GABA-ergic, serotonergic, glutamatergic agents) and non-pharmacological There is an increasing evidence that corticosteroids damage the hippocampus in rodents and in primates. Hippocampal atrophy induced by corticosteroids may play an important role in the pathogenesis of a range of neuropsychiatric disorders. Hippocampus is necessary for short-term memory consolidation and HPA axis regulation. Signs of hippocampal damage (HPA dysregulation in combination with memory impairment) are found in affective disorders, Alzheimer's disease and in posttraumatic stress disorder. MRI volumetry reveals reduced hippocampal volume in these diseases. Evidence supporting the %22glucocorticoid hypothesis%22 of psychiatric disorders is reviewed in the first part of the paper. Unresolved questions concerning temporary aspects of neurodegeneration, causality, reversibility, type of damage, factors increasing hippocampal vulnerability, and both pharmacological (CRH antagonists, antiglucocorticoid drugs, GABA-ergic, serotonergic, glutamatergic agents) and non-pharmacological (en)
Title	Hippocampal Damage Mediated by Corticosteroids a Neuropsychiatric Research Challenge Hippocampal Damage Mediated by Corticosteroids a Neuropsychiatric Research Challenge (en)
skos:prefLabel	Hippocampal Damage Mediated by Corticosteroids a Neuropsychiatric Research Challenge Hippocampal Damage Mediated by Corticosteroids a Neuropsychiatric Research Challenge (en)
skos:notation	RIV/00216208:11120/01:00003616!RIV12-MZ0-11120___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NF6489)
http://linked.open...iv/cisloPeriodika	Suppl. 2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Höschl, Cyril Hájek, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	681655
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/01:00003616
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Hippocampus; corticosteroids; affective disorders; posttraumatic stress disorder; Alzheimer's disease (en)
http://linked.open.../riv/klicoveSlovo	affective disorders Hippocampus Alzheimer's disease posttraumatic stress disorder corticosteroids
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[370F0B50B448]
http://linked.open...i/riv/nazevZdroje	European Archives of Psychiatry and Clinical Neuroscience
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Can administration of corticosteroids lead to structural changes in hippocampus? Prospective MRI study in human patients treated with high doses of corticosteroids.
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	251
http://linked.open...iv/tvurceVysledku	Hájek, Tomáš Höschl, Cyril
http://linked.open...ain/vavai/riv/wos	000207579000017
issn	0940-1334
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/BF03035134
http://localhost/t...ganizacniJednotka	11120

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