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  • The present study tested the hypothesis that exposure to morphine on prenatal days 11-18 impairs performance on tasks requiring learning and memory in adult male and female rats. In Experiment 1, a symmetrical maze was used to measure learning. In Experiment 2, an eight-arm radial maze was used to assess working spatial memory. The results of Experiment 1 demonstrated that prenatal morphine exposure reduces the time needed to complete the trials, but does not affect the accuracy of performance in male rats. In contrast, prenatal drug treatment had no effects on either the time or the accuracy of performance in female rats. In Experiment 2, both male and female morphine exposed rats needed more time to complete regular trials (no delay) than controls; however, morphine exposure in male rats did not affect performance on tasks requiring memory, measured with delay trials, but hindered it in ovariohysterectomized (OVX) female rats.
  • The present study tested the hypothesis that exposure to morphine on prenatal days 11-18 impairs performance on tasks requiring learning and memory in adult male and female rats. In Experiment 1, a symmetrical maze was used to measure learning. In Experiment 2, an eight-arm radial maze was used to assess working spatial memory. The results of Experiment 1 demonstrated that prenatal morphine exposure reduces the time needed to complete the trials, but does not affect the accuracy of performance in male rats. In contrast, prenatal drug treatment had no effects on either the time or the accuracy of performance in female rats. In Experiment 2, both male and female morphine exposed rats needed more time to complete regular trials (no delay) than controls; however, morphine exposure in male rats did not affect performance on tasks requiring memory, measured with delay trials, but hindered it in ovariohysterectomized (OVX) female rats. (en)
Title
  • Prenatal morphine exposure differentially alters learning and memory in male and female rats
  • Prenatal morphine exposure differentially alters learning and memory in male and female rats (en)
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  • Prenatal morphine exposure differentially alters learning and memory in male and female rats
  • Prenatal morphine exposure differentially alters learning and memory in male and female rats (en)
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  • RIV/00216208:11120/01:00003615!RIV12-MZ0-11120___
http://linked.open...avai/riv/aktivita
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  • 692512
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  • RIV/00216208:11120/01:00003615
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  • prenatal morphine; learning; spatial memory; gonadal hormones (en)
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  • GB - Spojené království Velké Británie a Severního Irska
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  • [637B7A51A2C5]
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  • Physiology & Behavior
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  • 73
http://linked.open...iv/tvurceVysledku
  • Pometlová, Marie
  • Šlamberová, Romana
http://linked.open...ain/vavai/riv/wos
  • 000169239400013
issn
  • 0031-9384
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/S0031-9384(01)00469-3
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  • 11120
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