About: Prenatal exposure to morphine differentially alters gonadal hormone regulation of delta-opioid receptor binding in male and female rats

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About: Prenatal exposure to morphine differentially alters gonadal hormone regulation of delta-opioid receptor binding in male and female rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/S0361-9230(00)00409-3
Description	The present study tested the hypothesis that exposure to morphine on gestation days 11-18 differentially alters delta -opioid receptors in the brain of adult male and female rats. In Experiment 1, the binding characteristics of delta -opioid receptors were examined in membrane homogenates from six brain regions, including the hypothalamus (HYP), preoptic area, frontal cortex (CX), ventral tegmental area, striatum (STR) and cerebellum of adult male and female rats. In Experiment 2, the density of delta -opioid receptors was assessed in the CX and STR using receptor autoradiography. Prenatal morphine exposure has no effects on delta -opioid receptors in the brain of gonadally intact, adult male rats regardless of methodology. However, when male rats were gonadectomized in Experiment 2, morphine-exposed males have fewer delta -opioid receptors than controls in the CX but not in the STR. These reductions in cortical delta -opioid receptors are restored by testosterone replacement, demonstrating that prena The present study tested the hypothesis that exposure to morphine on gestation days 11-18 differentially alters delta -opioid receptors in the brain of adult male and female rats. In Experiment 1, the binding characteristics of delta -opioid receptors were examined in membrane homogenates from six brain regions, including the hypothalamus (HYP), preoptic area, frontal cortex (CX), ventral tegmental area, striatum (STR) and cerebellum of adult male and female rats. In Experiment 2, the density of delta -opioid receptors was assessed in the CX and STR using receptor autoradiography. Prenatal morphine exposure has no effects on delta -opioid receptors in the brain of gonadally intact, adult male rats regardless of methodology. However, when male rats were gonadectomized in Experiment 2, morphine-exposed males have fewer delta -opioid receptors than controls in the CX but not in the STR. These reductions in cortical delta -opioid receptors are restored by testosterone replacement, demonstrating that prena (en)
Title	Prenatal exposure to morphine differentially alters gonadal hormone regulation of delta-opioid receptor binding in male and female rats Prenatal exposure to morphine differentially alters gonadal hormone regulation of delta-opioid receptor binding in male and female rats (en)
skos:prefLabel	Prenatal exposure to morphine differentially alters gonadal hormone regulation of delta-opioid receptor binding in male and female rats Prenatal exposure to morphine differentially alters gonadal hormone regulation of delta-opioid receptor binding in male and female rats (en)
skos:notation	RIV/00216208:11120/00:00003747!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 111200005)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Šlamberová, Romana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	722901
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/00:00003747
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	prenatal morphine; delta-opioid receptors; hypothalamus; preoptic area; cortex; striatum; ventral tegmental area; cerebellum; gonadal hormones (en)
http://linked.open.../riv/klicoveSlovo	hypothalamus cortex cerebellum delta-opioid receptors prenatal morphine preoptic area striatum ventral tegmental area gonadal hormones
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[66B623B09CC3]
http://linked.open...i/riv/nazevZdroje	Brain Research Bulletin
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	53
http://linked.open...iv/tvurceVysledku	Šlamberová, Romana Vathy, Ilona Rimanoczy, A.
http://linked.open...ain/vavai/riv/wos	000167060500009
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111200005
issn	0361-9230
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/S0361-9230(00)00409-3
http://localhost/t...ganizacniJednotka	11120

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