About: Gemcitabine in non-small cell lung cancer (NSCLC)     Goto   Sponge   NotDistinct   Permalink

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Description
  • The role of chemotherapy in the treatment of non-small cell lung cancer (NSCLC) has increased greatly in the past few years. While cytotoxic drugs are currently used both as single agents and in combination for palliation in locally advanced and metastatic disease, they have also been incorporated into multi-modality treatment strategies of Stage I to Stage III NSCLC. One of the main reasons for the increased acceptance of chemotherapy is the development of new substances. Among the most promising of these new drugs is the antimetabolite gemcitabine. Several single-arm gemcitabine Phase II studies involving more than 400 patients show validated response rates in more than 20% of the patients. These positive results have also been confirmed in randomized Phase II studies. Gemcitabine's unique mechanism of action, its lack of overlapping toxicity with other agents, and its favorable toxicity profile also define it as an ideal candidate for combination therapy. The activity seen with single-agent ge
  • The role of chemotherapy in the treatment of non-small cell lung cancer (NSCLC) has increased greatly in the past few years. While cytotoxic drugs are currently used both as single agents and in combination for palliation in locally advanced and metastatic disease, they have also been incorporated into multi-modality treatment strategies of Stage I to Stage III NSCLC. One of the main reasons for the increased acceptance of chemotherapy is the development of new substances. Among the most promising of these new drugs is the antimetabolite gemcitabine. Several single-arm gemcitabine Phase II studies involving more than 400 patients show validated response rates in more than 20% of the patients. These positive results have also been confirmed in randomized Phase II studies. Gemcitabine's unique mechanism of action, its lack of overlapping toxicity with other agents, and its favorable toxicity profile also define it as an ideal candidate for combination therapy. The activity seen with single-agent ge (en)
Title
  • Gemcitabine in non-small cell lung cancer (NSCLC)
  • Gemcitabine in non-small cell lung cancer (NSCLC) (en)
skos:prefLabel
  • Gemcitabine in non-small cell lung cancer (NSCLC)
  • Gemcitabine in non-small cell lung cancer (NSCLC) (en)
skos:notation
  • RIV/00216208:11120/00:00003719!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita
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  • 711782
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/00:00003719
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • gemcitabine; NSCLC; review; efficacy; toxicity; randomization (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [566475C6E879]
http://linked.open...i/riv/nazevZdroje
  • Investigational New Drugs
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 18
http://linked.open...iv/tvurceVysledku
  • Zatloukal, Petr
  • Manegold, Ch.
http://linked.open...ain/vavai/riv/wos
  • 000085801400004
issn
  • 0167-6997
number of pages
http://bibframe.org/vocab/doi
  • 10.1023/a:1006327729228
http://localhost/t...ganizacniJednotka
  • 11120
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