About: Human Epidermal Langerhans Cells Are Selectively Recognized by Galectin-3 but not by Galectin-1

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About: Human Epidermal Langerhans Cells Are Selectively Recognized by Galectin-3 but not by Galectin-1 Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Langerhans cells are dendritic antigen-presenting cells residing predominantly in the epidermis. Since endogenous galactoside-binding lectins with the jelly-roll moth (galectins) are known to trigger cellular responses, including mediator release, we investigated by lectin histochemistry the cells' capacity to bind two common members of this family, i.e. galectin-1 and -3. Actually, surrounding keratinocytes express a high level of galectin-3, and these cells can be considered as donors of this lectin to Langerhans cells. Employing biotinylated galectin-1 and -3, and concomitantly an antibody against CD1a as a second marker, to visualize the position of Langerhans cells in the human epidermis, the expression of galectin-3-reactive glycoligands in contrast to the lack of binding of galectin-1 was observed. Although the functional consequences of this selectivity are unclear, these results reveal an example for differential cellular reactivity towards two related endogenous lectins. Langerhans cells are dendritic antigen-presenting cells residing predominantly in the epidermis. Since endogenous galactoside-binding lectins with the jelly-roll moth (galectins) are known to trigger cellular responses, including mediator release, we investigated by lectin histochemistry the cells' capacity to bind two common members of this family, i.e. galectin-1 and -3. Actually, surrounding keratinocytes express a high level of galectin-3, and these cells can be considered as donors of this lectin to Langerhans cells. Employing biotinylated galectin-1 and -3, and concomitantly an antibody against CD1a as a second marker, to visualize the position of Langerhans cells in the human epidermis, the expression of galectin-3-reactive glycoligands in contrast to the lack of binding of galectin-1 was observed. Although the functional consequences of this selectivity are unclear, these results reveal an example for differential cellular reactivity towards two related endogenous lectins. (en)
Title	Human Epidermal Langerhans Cells Are Selectively Recognized by Galectin-3 but not by Galectin-1 Human Epidermal Langerhans Cells Are Selectively Recognized by Galectin-3 but not by Galectin-1 (en)
skos:prefLabel	Human Epidermal Langerhans Cells Are Selectively Recognized by Galectin-3 but not by Galectin-1 Human Epidermal Langerhans Cells Are Selectively Recognized by Galectin-3 but not by Galectin-1 (en)
skos:notation	RIV/00216208:11120/00:00003717!RIV12-MZ0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IZ4399), Z(MSM 111100005)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Dvořánková, Barbora
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	712857
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/00:00003717
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Langerhans cell; Galectin-1; Galectin-3; Endogenous lectin; Birbeck granule (en)
http://linked.open.../riv/klicoveSlovo	Galectin-3 Birbeck granule Endogenous lectin Galectin-1 Langerhans cell
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[F25506BF733E]
http://linked.open...i/riv/nazevZdroje	Folia Biologica
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	The new method of cultivation and transfer of human keratinocytes on polymer matrice for the treatment of severely burned patients
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	46
http://linked.open...iv/tvurceVysledku	Dvořánková, Barbora Holíková, Zuzana
http://linked.open...ain/vavai/riv/wos	000089990800008
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111100005
issn	0015-5500
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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