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Description
  • Several candidate genes have been proposed as potential biomarkers for altered pharmacodynamics or pharmacokinetics of immunosuppressive drugs. However, there is usually only limited clinical evidence substantiating the implementation of biomarkers into clinical practice. Testing for thiopurine-S-methyltransferase polymorphisms has been put into routine clinical use quite widely, while the other pharmacogenetic tests are much less frequently used. Relatively good evidence appeared for tacrolimus-related biomarkers; thus, their utilization may be envisaged in the near future. Although the biomarkers related to mycophenolate, sirolimus or other drugs in the therapeutic class may be promising, further research is necessary to provide more robust evidence. The present review focuses on immunosuppressive drugs, excluding biological treatment.
  • Several candidate genes have been proposed as potential biomarkers for altered pharmacodynamics or pharmacokinetics of immunosuppressive drugs. However, there is usually only limited clinical evidence substantiating the implementation of biomarkers into clinical practice. Testing for thiopurine-S-methyltransferase polymorphisms has been put into routine clinical use quite widely, while the other pharmacogenetic tests are much less frequently used. Relatively good evidence appeared for tacrolimus-related biomarkers; thus, their utilization may be envisaged in the near future. Although the biomarkers related to mycophenolate, sirolimus or other drugs in the therapeutic class may be promising, further research is necessary to provide more robust evidence. The present review focuses on immunosuppressive drugs, excluding biological treatment. (en)
Title
  • Pharmacogenetics and immunosuppressive drugs
  • Pharmacogenetics and immunosuppressive drugs (en)
skos:prefLabel
  • Pharmacogenetics and immunosuppressive drugs
  • Pharmacogenetics and immunosuppressive drugs (en)
skos:notation
  • RIV/00216208:11110/14:10286424!RIV15-MSM-11110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 6
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  • 36378
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11110/14:10286424
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  • recipient; pharmacokinetics; pharmacogenomics; pharmacodynamics; immunosuppressants; donor (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [7A53EEDAEC23]
http://linked.open...i/riv/nazevZdroje
  • Expert Review of Clinical Pharmacology
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http://linked.open...v/svazekPeriodika
  • 7
http://linked.open...iv/tvurceVysledku
  • Slanař, Ondřej
  • Matoušková, Olga
  • Světlík, Svatopluk
  • Hronová, Karolína
  • Šíma, Martin
http://linked.open...ain/vavai/riv/wos
  • 000350022400012
issn
  • 1751-2433
number of pages
http://bibframe.org/vocab/doi
  • 10.1586/17512433.2014.966811
http://localhost/t...ganizacniJednotka
  • 11110
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