About: Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases

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About: Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1038/tpj.2014.3
Description	Clinical response to methotrexate (MTX) treatment for children with juvenile idiopathic arthritis (JIA) displays considerable heterogeneity. Currently, there are no reliable predictors to identify non-responders: earlier identification could lead to a targeted treatment. We genotyped 759 JIA cases from the UK, the Netherlands and Czech Republic. Clinical variables were measured at baseline and 6 months after start of the treatment. In Phase I analysis, samples were analysed for the association with MTX response using ordinal regression of ACR-pedi categories and linear regression of change in clinical variables, and identified 31 genetic regions (P<0.001). Phase II analysis increased SNP density in the most strongly associated regions, identifying 14 regions (P < 1 x 10(-5)): three contain genes of particular biological interest (ZMIZ1, TGIF1 and CFTR). These data suggest a role for novel pathways in MTX response and further investigations within associated regions will help to reach our goal of predicting response to MTX in JIA. Clinical response to methotrexate (MTX) treatment for children with juvenile idiopathic arthritis (JIA) displays considerable heterogeneity. Currently, there are no reliable predictors to identify non-responders: earlier identification could lead to a targeted treatment. We genotyped 759 JIA cases from the UK, the Netherlands and Czech Republic. Clinical variables were measured at baseline and 6 months after start of the treatment. In Phase I analysis, samples were analysed for the association with MTX response using ordinal regression of ACR-pedi categories and linear regression of change in clinical variables, and identified 31 genetic regions (P<0.001). Phase II analysis increased SNP density in the most strongly associated regions, identifying 14 regions (P < 1 x 10(-5)): three contain genes of particular biological interest (ZMIZ1, TGIF1 and CFTR). These data suggest a role for novel pathways in MTX response and further investigations within associated regions will help to reach our goal of predicting response to MTX in JIA. (en)
Title	Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases (en)
skos:prefLabel	Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases (en)
skos:notation	RIV/00216208:11110/14:10286356!RIV15-MSM-11110___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Doležalová, Pavla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	18146
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/14:10286356
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cases; arthritis; idiopathic; juvenile; cohort; large; response; methotrexate; for; genes; novel; reveal; data; Genome-wide (en)
http://linked.open.../riv/klicoveSlovo	Genome-wide reveal large arthritis cases data for idiopathic response genes novel methotrexate cohort juvenile
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3DB29D255AFE]
http://linked.open...i/riv/nazevZdroje	Pharmacogenomics Journal
http://linked.open...in/vavai/riv/obor	FG
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	21 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Doležalová, Pavla Wulffraat, N. Bohm, M. Bulatovič, M. Cobb, J. Cule, E. Flynn, E. Hinks, A. Kassoumeri, L. Moncrieffe, H. Patrick, F. Ursu, S. de Jonge, R. van Zeist, B.
http://linked.open...ain/vavai/riv/wos	000340216000008
issn	1470-269X
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1038/tpj.2014.3
http://localhost/t...ganizacniJednotka	11110

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