About: 6S RNA modulates growth and antibiotic production in Streptomyces coelicolor

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: 6S RNA modulates growth and antibiotic production in Streptomyces coelicolor Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1007/s00253-014-5806-4
Description	The aim of this study was to contribute to clarifying the role of 6S RNA in the development and control of antibiotic biosynthesis in Streptomyces coelicolor. Due to the low energetic cost of gene silencing via 6S RNA, it is an easy and rapid means of down-regulating the expression of specific genes in response to signals from changes in the environment. The expression of 6S RNA in S. coelicolor is not constitutive, and its accumulation is adapted to changes in nutritional conditions. The 6S RNA of S. coelicolor is capable of interacting with RNA polymerase beta beta' subunits and is a template for the transcription of short pRNAs. Deletion of the ssrS gene from S. coelicolor affects the growth rate and causes changes in the expression of several pathway-specific genes involved in actinorhodin biosynthesis. The complementation of the Delta ssrS strain with ssrS gene restored the wild-type levels of growth and actinorhodin production. We conclude that 6S RNA contributes to the optimization of cellular adaptation and is an important factor involved in the regulation of growth and expression of key genes for the biosynthesis of actinorhodin. The aim of this study was to contribute to clarifying the role of 6S RNA in the development and control of antibiotic biosynthesis in Streptomyces coelicolor. Due to the low energetic cost of gene silencing via 6S RNA, it is an easy and rapid means of down-regulating the expression of specific genes in response to signals from changes in the environment. The expression of 6S RNA in S. coelicolor is not constitutive, and its accumulation is adapted to changes in nutritional conditions. The 6S RNA of S. coelicolor is capable of interacting with RNA polymerase beta beta' subunits and is a template for the transcription of short pRNAs. Deletion of the ssrS gene from S. coelicolor affects the growth rate and causes changes in the expression of several pathway-specific genes involved in actinorhodin biosynthesis. The complementation of the Delta ssrS strain with ssrS gene restored the wild-type levels of growth and actinorhodin production. We conclude that 6S RNA contributes to the optimization of cellular adaptation and is an important factor involved in the regulation of growth and expression of key genes for the biosynthesis of actinorhodin. (en)
Title	6S RNA modulates growth and antibiotic production in Streptomyces coelicolor 6S RNA modulates growth and antibiotic production in Streptomyces coelicolor (en)
skos:prefLabel	6S RNA modulates growth and antibiotic production in Streptomyces coelicolor 6S RNA modulates growth and antibiotic production in Streptomyces coelicolor (en)
skos:notation	RIV/00216208:11110/14:10285295!RIV15-MSM-11110___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP302/10/0468), P(IAA600110902)
http://linked.open...iv/cisloPeriodika	16
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Bobek, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	58346
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/14:10285295
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Actinorhodin; Streptomyces coelicolor; pRNAs; Secondary structure; 6SRNA (en)
http://linked.open.../riv/klicoveSlovo	6SRNA Actinorhodin Secondary structure Streptomyces coelicolor pRNAs
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[50A017BB4D54]
http://linked.open...i/riv/nazevZdroje	Applied Microbiology and Biotechnology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Influence of ingestion of anthropogenically contaminated soils by heavy metals on changes of biochemical and physiological parameters of rats Analysis and modelling of gene expression in search for regulatory RNAs affecting antibiotic production in Streptomyces
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	98
http://linked.open...iv/tvurceVysledku	Bobek, Jan Mikulik, Karel Zidkova, Jarmila Felsberg, Jurgen
http://linked.open...ain/vavai/riv/wos	000340087600026
issn	0175-7598
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00253-014-5806-4
http://localhost/t...ganizacniJednotka	11110

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software