About: Different effects of lobeline on neuronal and muscle nicotinic receptors

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.ejphar.2014.05.057
Description	Lobeline is a plant alkaloid known to interact with cholinergic system. The effect of lobeline on neuronal alpha 3 beta 4 receptors expressed in COS cells and muscle embryonic alpha beta gamma delta receptors naturally expressed in TE671 cells was studied using a patch clamp technique. Our results show that lobeline inhibited responses to acetylcholine in human embryonic muscle nicotinic receptor in a pseudo noncompetitive manner. The responses of rat neuronal alpha 3 beta 4 receptors to a low concentration of acetylcholine were potentiated by a mixed occupation mechanism that corresponds to %22competitive potentiation%22. This potentiation turned into voltage dependent inhibition for alpha 3 beta 4 receptors was activated by a high concentration of acetylcholine. Lobeline is a plant alkaloid known to interact with cholinergic system. The effect of lobeline on neuronal alpha 3 beta 4 receptors expressed in COS cells and muscle embryonic alpha beta gamma delta receptors naturally expressed in TE671 cells was studied using a patch clamp technique. Our results show that lobeline inhibited responses to acetylcholine in human embryonic muscle nicotinic receptor in a pseudo noncompetitive manner. The responses of rat neuronal alpha 3 beta 4 receptors to a low concentration of acetylcholine were potentiated by a mixed occupation mechanism that corresponds to %22competitive potentiation%22. This potentiation turned into voltage dependent inhibition for alpha 3 beta 4 receptors was activated by a high concentration of acetylcholine. (en)
Title	Different effects of lobeline on neuronal and muscle nicotinic receptors Different effects of lobeline on neuronal and muscle nicotinic receptors (en)
skos:prefLabel	Different effects of lobeline on neuronal and muscle nicotinic receptors Different effects of lobeline on neuronal and muscle nicotinic receptors (en)
skos:notation	RIV/00216208:11110/14:10285285!RIV15-MSM-11110___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GA202/09/0806), P(GBP304/12/G069), P(IAA500110905)
http://linked.open...iv/cisloPeriodika	June
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Adámek, Svatopluk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	11456
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/14:10285285
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Lobeline; Embryonic muscle nicotinic receptor; Neuronal nicotinic receptor alpha3beta4 (en)
http://linked.open.../riv/klicoveSlovo	Embryonic muscle nicotinic receptor Lobeline Neuronal nicotinic receptor alpha3beta4
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[2508F55A3774]
http://linked.open...i/riv/nazevZdroje	European Journal of Pharmacology
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Project of excellence in the field of neuroscience Cooperativity of nicotinic receptors Acetylcholine release and nicotinic receptor
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	738
http://linked.open...iv/tvurceVysledku	Vyskočil, František Adámek, Svatopluk Kaniakova, Martina Krusek, Jan Skřenková, Kristýna
http://linked.open...ain/vavai/riv/wos	000339998000044
issn	0014-2999
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ejphar.2014.05.057
http://localhost/t...ganizacniJednotka	11110

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