About: DNA methylation markers for early detection of women's cancer: promise and challenges

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.2217/EPI.14.20
Description	Breast, ovarian and endometrial cancers cause significant morbidity and mortality. Despite the presence of existing screening, diagnostic and treatment modalities, they continue to pose considerable unsolved challenges. Overdiagnosis is a growing problem in breast cancer screening and neither screening nor early diagnosis of ovarian or endometrial cancer is currently possible. Moreover, treatment of the diversity of these cancers presenting in the clinic is not sufficiently personalized at present. Recent technological advances, including reduced representation bisulfite sequencing, methylation arrays, digital PCR, next-generation sequencing and advanced statistical data analysis, enable the analysis of methylation patterns in cell-free tumor DNA in serum/plasma. Ongoing work is bringing these methods together for the analysis of samples from large clinical trials, which have been collected well in advance of cancer diagnosis. These efforts pave the way for the development of a noninvasive method that would enable us to overcome existing challenges to personalized medicine. Breast, ovarian and endometrial cancers cause significant morbidity and mortality. Despite the presence of existing screening, diagnostic and treatment modalities, they continue to pose considerable unsolved challenges. Overdiagnosis is a growing problem in breast cancer screening and neither screening nor early diagnosis of ovarian or endometrial cancer is currently possible. Moreover, treatment of the diversity of these cancers presenting in the clinic is not sufficiently personalized at present. Recent technological advances, including reduced representation bisulfite sequencing, methylation arrays, digital PCR, next-generation sequencing and advanced statistical data analysis, enable the analysis of methylation patterns in cell-free tumor DNA in serum/plasma. Ongoing work is bringing these methods together for the analysis of samples from large clinical trials, which have been collected well in advance of cancer diagnosis. These efforts pave the way for the development of a noninvasive method that would enable us to overcome existing challenges to personalized medicine. (en)
Title	DNA methylation markers for early detection of women's cancer: promise and challenges DNA methylation markers for early detection of women's cancer: promise and challenges (en)
skos:prefLabel	DNA methylation markers for early detection of women's cancer: promise and challenges DNA methylation markers for early detection of women's cancer: promise and challenges (en)
skos:notation	RIV/00216208:11110/14:10284747!RIV15-MSM-11110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(7E13033)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Zikán, Michal Cibula, David
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	12002
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/14:10284747
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	serum; screening; reduced representation bisulfite sequencing; plasma; personalized medicine; methylation arrays; epigenetics; DNA methylation; digital PCR; circulating cell-free DNA; cancer (en)
http://linked.open.../riv/klicoveSlovo	digital PCR methylation arrays reduced representation bisulfite sequencing cancer plasma screening epigenetics serum circulating cell-free DNA DNA methylation personalized medicine
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[77FB088CC201]
http://linked.open...i/riv/nazevZdroje	Epigenomics
http://linked.open...in/vavai/riv/obor	FK
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...vavai/riv/projekt	Epigenetics for female personalized cancer care
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Cibula, David Zikán, Michal Widschwendter, Martin Jones, Allison Alunni-Fabbroni, Marianna Evans, Iona Koch, Julian Lempiaeinen, Harri Paprotka, Tobias Rack, Brigitte Reisel, Daniel Rujan, Tamas Sleigh, Sara Wahl, Benjamin Wittenberger, Timo
http://linked.open...ain/vavai/riv/wos	000340668300013
issn	1750-1911
number of pages	17 (xsd:int)
http://bibframe.org/vocab/doi	10.2217/EPI.14.20
http://localhost/t...ganizacniJednotka	11110

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