About: Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies

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About: Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.biomedcentral.com/content/pdf/s13075-014-0454-8.pdf
Description	Anti-Jo-1 and anti-Ro52 autoantibodies are common in patients with myositis. Survival of autoantibody-producing cells is dependent on B-cell-activating factor of the tumour necrosis factor family (BAFF). BAFF levels are elevated in serum of anti-Jo-1-positive myositis patients and are influenced by type-I interferon (IFN). IFN-producing cells and BAFF mRNA expression are present in myositis muscle. We have investigated expression of the receptors for BAFF in muscle tissue and found their association to serum autoantibodies and muscle expression of type-I IFN markers. The expression pattern of receptors for BAFF on B and plasma cells in muscle suggests a possible local role for BAFF in autoantibody production in muscle tissues of patients with myositis who have anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies. Anti-Jo-1 and anti-Ro52 autoantibodies are common in patients with myositis. Survival of autoantibody-producing cells is dependent on B-cell-activating factor of the tumour necrosis factor family (BAFF). BAFF levels are elevated in serum of anti-Jo-1-positive myositis patients and are influenced by type-I interferon (IFN). IFN-producing cells and BAFF mRNA expression are present in myositis muscle. We have investigated expression of the receptors for BAFF in muscle tissue and found their association to serum autoantibodies and muscle expression of type-I IFN markers. The expression pattern of receptors for BAFF on B and plasma cells in muscle suggests a possible local role for BAFF in autoantibody production in muscle tissues of patients with myositis who have anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies. (en)
Title	Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies (en)
skos:prefLabel	Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies (en)
skos:notation	RIV/00216208:11110/14:10284516!RIV15-MSM-11110___
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Vencovský, Jiří Kryštůfková, Olga
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	16156
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/14:10284516
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	myositis; autoantibodies; BCMA; TACI; BAFF-R; BAFF (en)
http://linked.open.../riv/klicoveSlovo	BAFF autoantibodies myositis BAFF-R BCMA TACI
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[7EF7D2D10644]
http://linked.open...i/riv/nazevZdroje	Arthritis Research and Therapy
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Vencovský, Jiří Kryštůfková, Olga Lundberg, I.E. Barbasso Helmers, S. Lindroos, E. Malmström, W. Venalis, P.
http://linked.open...ain/vavai/riv/wos	000349885900033
issn	1478-6354
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/s13075-014-0454-8
http://localhost/t...ganizacniJednotka	11110

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