About: Pitfalls in the Laboratory Assessment of serum prealbumin levels in hemato-oncological patients

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About: Pitfalls in the Laboratory Assessment of serum prealbumin levels in hemato-oncological patients Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://europepmc.org/abstract/med/25648039
Description	Background: To highlight specific aspects of serum prealbumin measurements in hemato-oncological patients. Methods: Retrospective analysis of 4911 serum prealbumin measurements with special attention to values from hemato-oncological Intensive Care Units (ICU) patients. Results: Prealbumin serum levels in hemato-oncological ICU patients (n = 530) were significantly higher when compared to other ICU cohorts (p < 0.0001). Their prealbuminemia did not correlate with serum albumin (p = 0.104) and was not affected by serum cholesterol or triglycerides (p = 0.076 and p = 0.430, respectively). Surprisingly, serum prealbumin has shown a positive correlation with cyclosporine in whole blood levels (r = 0.269, p = 0.010). Conclusions: A supposed explanation for our findings probably lies in a combination of several factors, including interference with the analysis itself and contamination or possible interference with the medication, e.g., cyclosporine. The prealbumin values do not reflect the actual nutritional state and cannot be regarded as a useful marker of malnutrition in these patients. Background: To highlight specific aspects of serum prealbumin measurements in hemato-oncological patients. Methods: Retrospective analysis of 4911 serum prealbumin measurements with special attention to values from hemato-oncological Intensive Care Units (ICU) patients. Results: Prealbumin serum levels in hemato-oncological ICU patients (n = 530) were significantly higher when compared to other ICU cohorts (p < 0.0001). Their prealbuminemia did not correlate with serum albumin (p = 0.104) and was not affected by serum cholesterol or triglycerides (p = 0.076 and p = 0.430, respectively). Surprisingly, serum prealbumin has shown a positive correlation with cyclosporine in whole blood levels (r = 0.269, p = 0.010). Conclusions: A supposed explanation for our findings probably lies in a combination of several factors, including interference with the analysis itself and contamination or possible interference with the medication, e.g., cyclosporine. The prealbumin values do not reflect the actual nutritional state and cannot be regarded as a useful marker of malnutrition in these patients. (en)
Title	Pitfalls in the Laboratory Assessment of serum prealbumin levels in hemato-oncological patients Pitfalls in the Laboratory Assessment of serum prealbumin levels in hemato-oncological patients (en)
skos:prefLabel	Pitfalls in the Laboratory Assessment of serum prealbumin levels in hemato-oncological patients Pitfalls in the Laboratory Assessment of serum prealbumin levels in hemato-oncological patients (en)
skos:notation	RIV/00216208:11110/14:10284028!RIV15-MSM-11110___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Zima, Tomáš Malíčková, Karin Brodská, Helena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	36699
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/14:10284028
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cyclosporine; hematooncology, Intensive Care Units; prealbumin (en)
http://linked.open.../riv/klicoveSlovo	Intensive Care Units prealbumin cyclosporine hematooncology
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[5D34A3AC20A6]
http://linked.open...i/riv/nazevZdroje	Clinical Laboratory
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	60
http://linked.open...iv/tvurceVysledku	Brodská, Helena Malíčková, Karin Zima, Tomáš Šťastná-Marková, Markéta
http://linked.open...ain/vavai/riv/wos	000344911700023
issn	1433-6510
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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