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Description
  • The role of complement has been demonstrated in experimental models of neuromyelitis optica (NMO), however, only few studies have analysed complement components longitudinally in NMO patients. We measured serum or plasma concentrations of anti-C1q antibodies and complement split products C3a and C4a and soluble C5b-9 in patients with NMO, multiple sclerosis and healthy controls. NMO patients had higher levels of C3a and anti-C1q antibodies than healthy controls. C3a levels correlated with disease activity, neurological disability and aquaporin-4 IgG in NMO patients suggesting a role of the alternative pathway of complement in the pathogenesis of NMO and supporting the strategy of therapeutic complement inhibition.
  • The role of complement has been demonstrated in experimental models of neuromyelitis optica (NMO), however, only few studies have analysed complement components longitudinally in NMO patients. We measured serum or plasma concentrations of anti-C1q antibodies and complement split products C3a and C4a and soluble C5b-9 in patients with NMO, multiple sclerosis and healthy controls. NMO patients had higher levels of C3a and anti-C1q antibodies than healthy controls. C3a levels correlated with disease activity, neurological disability and aquaporin-4 IgG in NMO patients suggesting a role of the alternative pathway of complement in the pathogenesis of NMO and supporting the strategy of therapeutic complement inhibition. (en)
Title
  • Complement activation in patients with neuromyelitis optica
  • Complement activation in patients with neuromyelitis optica (en)
skos:prefLabel
  • Complement activation in patients with neuromyelitis optica
  • Complement activation in patients with neuromyelitis optica (en)
skos:notation
  • RIV/00216208:11110/14:10272276!RIV15-MSM-11110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, S
http://linked.open...iv/cisloPeriodika
  • 1-2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 8333
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11110/14:10272276
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Neuromyelitis optica; Complement; C1q antibodies; Aquaporin-4 IgG (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [0302505CFD68]
http://linked.open...i/riv/nazevZdroje
  • Journal of Neuroimmunology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 274
http://linked.open...iv/tvurceVysledku
  • Havrdová, Eva
  • Kemlink, David
  • Horáková, Dana
  • Potluková, Eliška
  • Nytrová, Petra
  • Trendelenburg, Marten
  • Živorová, Dana
  • Vincent, Angela
  • Waters, Patrick
  • Woodhall, Mark
http://linked.open...ain/vavai/riv/wos
  • 000342871600024
issn
  • 0165-5728
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.jneuroim.2014.07.001
http://localhost/t...ganizacniJednotka
  • 11110
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