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Description
| - Cancer-associated fibroblasts (CAFs) play a role in the progression of malignant tumors. They are formed by conversion of fibroblasts to smooth muscle alpha-actin-positive (SMA-positive) myofibroblasts. Polyamines are known to change the arrangement of the actin cytoskeleton by binding to the anionic actin. We tested the effect of the synthetic polyamine BPA-C8 on the transition of human dermal fibroblasts to myofibroblasts induced either by TGF-beta 1 alone or by TGF-beta 1 together with adhesion/growth-regulatory galectin-1. Pre-existing CAFs, myofi-broblasts from pancreatitis, and rat smooth muscle cells were also exposed to BPA-C8. BPA-C8 impaired myofibroblast formation from activated fibroblasts, but it had no effect on cells already expressing SMA. BPA-C8 also reduced the occurrence of an extracellular matrix around the activated fibroblasts. The reported data thus extend current insights into polyamine activity, adding interference with tumor progression to the tumor-promoting processes warranting study.
- Cancer-associated fibroblasts (CAFs) play a role in the progression of malignant tumors. They are formed by conversion of fibroblasts to smooth muscle alpha-actin-positive (SMA-positive) myofibroblasts. Polyamines are known to change the arrangement of the actin cytoskeleton by binding to the anionic actin. We tested the effect of the synthetic polyamine BPA-C8 on the transition of human dermal fibroblasts to myofibroblasts induced either by TGF-beta 1 alone or by TGF-beta 1 together with adhesion/growth-regulatory galectin-1. Pre-existing CAFs, myofi-broblasts from pancreatitis, and rat smooth muscle cells were also exposed to BPA-C8. BPA-C8 impaired myofibroblast formation from activated fibroblasts, but it had no effect on cells already expressing SMA. BPA-C8 also reduced the occurrence of an extracellular matrix around the activated fibroblasts. The reported data thus extend current insights into polyamine activity, adding interference with tumor progression to the tumor-promoting processes warranting study. (en)
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Title
| - Synthetic Polyamine BPA-C8 Inhibits TGF-beta 1-Mediated Conversion of Human Dermal Fibroblast to Myofibroblasts and Establishment of Galectin-1-Rich Extracellular Matrix in Vitro
- Synthetic Polyamine BPA-C8 Inhibits TGF-beta 1-Mediated Conversion of Human Dermal Fibroblast to Myofibroblasts and Establishment of Galectin-1-Rich Extracellular Matrix in Vitro (en)
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skos:prefLabel
| - Synthetic Polyamine BPA-C8 Inhibits TGF-beta 1-Mediated Conversion of Human Dermal Fibroblast to Myofibroblasts and Establishment of Galectin-1-Rich Extracellular Matrix in Vitro
- Synthetic Polyamine BPA-C8 Inhibits TGF-beta 1-Mediated Conversion of Human Dermal Fibroblast to Myofibroblasts and Establishment of Galectin-1-Rich Extracellular Matrix in Vitro (en)
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skos:notation
| - RIV/00216208:11110/14:10272179!RIV15-MSM-11110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11110/14:10272179
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - tenascin; polycations; galectin; cancer; actin (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Chembiochem : a European journal of chemical biology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Dvořánková, Barbora
- Gabius, Hans-Joachim
- Kodet, Ondřej
- Kučera, Jan
- Smetana, Karel
- Szabo, Pavol
- Andre, Sabine
- Koripelly, Girish
- Lehn, Jean-Marie
- Mifková, Alžběta
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
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http://localhost/t...ganizacniJednotka
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