About: Modeling tumorigenesis in Drosophila: Current Advances and Future Perspectives

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdfs:seeAlso	http://dx.doi.org/10.5772/55686
Description	Cancer is essentially considered as a genetic disease caused by the accumulation of multiple genetic or epigenetic lesions in tumor-suppressor genes and oncogenes [1]. Although the notion that retinoblastoma could be an inherited disease was already formulated at the end of the 19th Century a solid genetic basis was established with the discovery of both proto-oncogenes, whose gain-of function mutations or altered expression is associated with the cancerous state, and tumor suppressor genes (TSGs), whose inactivation releases the %22brakes%22 inhibiting cell proliferation. Analysis of both proto-oncogenes and TSGs revealed also that cancer results from an alteration of the normal pathway of cell fate and differentiation. The hallmarks of cancer, as laid down by Hanahan and Weinberg to explain the complex biology of cancer, comprise six major developmental changes taking successively place in human tumors. These cancer %22characteristics%22 include sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, replicative immortality, angiogenesis as well as cell invasion and metastasis. Underlying these hallmarks are genome instability, inflammation, reprogramming of energy metabolism and evading immune destruction [2]. Cancer is essentially considered as a genetic disease caused by the accumulation of multiple genetic or epigenetic lesions in tumor-suppressor genes and oncogenes [1]. Although the notion that retinoblastoma could be an inherited disease was already formulated at the end of the 19th Century a solid genetic basis was established with the discovery of both proto-oncogenes, whose gain-of function mutations or altered expression is associated with the cancerous state, and tumor suppressor genes (TSGs), whose inactivation releases the %22brakes%22 inhibiting cell proliferation. Analysis of both proto-oncogenes and TSGs revealed also that cancer results from an alteration of the normal pathway of cell fate and differentiation. The hallmarks of cancer, as laid down by Hanahan and Weinberg to explain the complex biology of cancer, comprise six major developmental changes taking successively place in human tumors. These cancer %22characteristics%22 include sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, replicative immortality, angiogenesis as well as cell invasion and metastasis. Underlying these hallmarks are genome instability, inflammation, reprogramming of energy metabolism and evading immune destruction [2]. (en)
Title	Modeling tumorigenesis in Drosophila: Current Advances and Future Perspectives Modeling tumorigenesis in Drosophila: Current Advances and Future Perspectives (en)
skos:prefLabel	Modeling tumorigenesis in Drosophila: Current Advances and Future Perspectives Modeling tumorigenesis in Drosophila: Current Advances and Future Perspectives (en)
skos:notation	RIV/00216208:11110/13:10195048!RIV14-GA0-11110___
http://linked.open...avai/predkladatel	1. lékařská fakulta
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP302/11/1640)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Mechler, Bernard
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	88913
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/13:10195048
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Drosophila; tumorigenesis; Modeling (en)
http://linked.open.../riv/klicoveSlovo	Modeling Drosophila tumorigenesis
http://linked.open...ontrolniKodProRIV	[3F37A0BB6F0F]
http://linked.open...i/riv/mistoVydani	Rijeka, Croatia
http://linked.open...vEdiceCisloSvazku	1
http://linked.open...i/riv/nazevZdroje	Future Aspects of Tumor Suppressor Gene
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...v/pocetStranKnihy	221 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Morphological features and molecular determinants of apocrine secretion
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Mechler, Bernard Papagiannouli, Fani
number of pages	29 (xsd:int)
http://bibframe.org/vocab/doi	10.5772/55686
http://purl.org/ne...btex#hasPublisher	InTech
https://schema.org/isbn	978-953-51-1063-7
http://localhost/t...ganizacniJednotka	11110

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