About: Chelating polymeric particles intended for the therapy of Wilson's disease

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.reactfunctpolym.2013.07.010
Description	Wilson's disease is a genetic disorder that leads to a high accumulation of copper in multiple organs with subsequent toxic effects. In this paper, a gentle therapy to eliminate harmful copper concentrations in patients with Wilson's disease is proposed using an oral administration of insoluble polymeric sorbents containing selective chelating groups for copper(II). The sorbents contained triethylenetetramine, N,N-di(2-pyridylmethyl)amine, 8-hydroxyquinoline or 8-hydroxyquinoline-5-sulfonic acid chelating groups bound to a methacrylate-based macroporous support. Nearly quantitative copper(II) uptake within minutes was achieved in buffers modeling the pH range present in the gastric environment (pH 2.0 and 4.0). The sorbents demonstrated chelating selectivity for copper(II) against zinc(II) with ratios of up to 1321. The sorbents demonstrated sufficient stability of the copper complexes against rechelation using studies in a model environment for the small intestine (the presence of chelating amino acids, pH 6.8). Wilson's disease is a genetic disorder that leads to a high accumulation of copper in multiple organs with subsequent toxic effects. In this paper, a gentle therapy to eliminate harmful copper concentrations in patients with Wilson's disease is proposed using an oral administration of insoluble polymeric sorbents containing selective chelating groups for copper(II). The sorbents contained triethylenetetramine, N,N-di(2-pyridylmethyl)amine, 8-hydroxyquinoline or 8-hydroxyquinoline-5-sulfonic acid chelating groups bound to a methacrylate-based macroporous support. Nearly quantitative copper(II) uptake within minutes was achieved in buffers modeling the pH range present in the gastric environment (pH 2.0 and 4.0). The sorbents demonstrated chelating selectivity for copper(II) against zinc(II) with ratios of up to 1321. The sorbents demonstrated sufficient stability of the copper complexes against rechelation using studies in a model environment for the small intestine (the presence of chelating amino acids, pH 6.8). (en)
Title	Chelating polymeric particles intended for the therapy of Wilson's disease Chelating polymeric particles intended for the therapy of Wilson's disease (en)
skos:prefLabel	Chelating polymeric particles intended for the therapy of Wilson's disease Chelating polymeric particles intended for the therapy of Wilson's disease (en)
skos:notation	RIV/00216208:11110/13:10191979!RIV14-GA0-11110___
http://linked.open...avai/predkladatel	1. lékařská fakulta
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GA13-08336S), P(GAP304/12/0950)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Urbánek, Petr Mattová, Jana Poučková, Pavla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	65201
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/13:10191979
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Amines; Selective sorbent; Copper metabolism; Polymer beads; Wilson's disease (en)
http://linked.open.../riv/klicoveSlovo	Amines Copper metabolism Polymer beads Selective sorbent Wilson's disease
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[761EE16680CF]
http://linked.open...i/riv/nazevZdroje	Reactive and Functional Polymers
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Hybridní materiály založené na makrocyklických ligandech pro využití v medicíně Chelating polymers as therapeuticals for Wilson´s disease
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	73
http://linked.open...iv/tvurceVysledku	Hrubý, Martin Poučková, Pavla Urbánek, Petr Štěpánek, Petr Kučka, Jan Sedláček, Ondřej Skopal, Jan Škodová, Michaela Vetrik, Miroslav Mattová, Jana Walterova, Zuzana
http://linked.open...ain/vavai/riv/wos	000326431800004
issn	1381-5148
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.reactfunctpolym.2013.07.010
http://localhost/t...ganizacniJednotka	11110

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