About: MITF: a Critical Transcription Factor in Melanoma Transcriptional Regulatory Network

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About: MITF: a Critical Transcription Factor in Melanoma Transcriptional Regulatory Network Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.5772/55191
Description	Melanocytes are specialized cells found predominantly in the skin and eyes that form the pigment melanin. Melanocytes are found also in a benign nevus, a common lesion observed in the skin which is a precursor of malignant melanoma. Sporadic cases of melanoma predominate and can be grouped into four clinical subtypes: acral lentiginous melanoma, nodular melanoma, lentigo maligna and superficial spreading melanoma. About 60-70% of melanomas harbour mutations of the B-RAF gene, while mutations of the N-RAS are present in about 10-25% of all tumors. Many other genes are deregulated during melanoma progression, mainly antiapoptotic genes and gene which are involved in the invasiveness, migration, and metastasis of melanoma, many of which are regulated by MITF-M (microphthalmia-associated transcription factor), a pivotal transcription factor of the melanocyte lineage. Melanocytes are specialized cells found predominantly in the skin and eyes that form the pigment melanin. Melanocytes are found also in a benign nevus, a common lesion observed in the skin which is a precursor of malignant melanoma. Sporadic cases of melanoma predominate and can be grouped into four clinical subtypes: acral lentiginous melanoma, nodular melanoma, lentigo maligna and superficial spreading melanoma. About 60-70% of melanomas harbour mutations of the B-RAF gene, while mutations of the N-RAS are present in about 10-25% of all tumors. Many other genes are deregulated during melanoma progression, mainly antiapoptotic genes and gene which are involved in the invasiveness, migration, and metastasis of melanoma, many of which are regulated by MITF-M (microphthalmia-associated transcription factor), a pivotal transcription factor of the melanocyte lineage. (en)
Title	MITF: a Critical Transcription Factor in Melanoma Transcriptional Regulatory Network MITF: a Critical Transcription Factor in Melanoma Transcriptional Regulatory Network (en)
skos:prefLabel	MITF: a Critical Transcription Factor in Melanoma Transcriptional Regulatory Network MITF: a Critical Transcription Factor in Melanoma Transcriptional Regulatory Network (en)
skos:notation	RIV/00216208:11110/13:10191824!RIV14-MZ0-11110___
http://linked.open...avai/predkladatel	1. lékařská fakulta
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NT11229)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Ondrušová, Ľubica Vachtenheim, Jiří
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	88556
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/13:10191824
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	transcription factor, SWI/SNF; microphthalmia, MITF; melanoma (en)
http://linked.open.../riv/klicoveSlovo	MITF SWI/SNF microphthalmia melanoma transcription factor
http://linked.open...ontrolniKodProRIV	[887804A66076]
http://linked.open...i/riv/mistoVydani	Rijeka, Croatia
http://linked.open...vEdiceCisloSvazku	Neuveden
http://linked.open...i/riv/nazevZdroje	Recent Advances in the Biology, Therapy and Management of Melanoma
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...v/pocetStranKnihy	375 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Transcription factor MITF – critical regulator of proliferation and viability of melanoma cells and a target of molecular anticancer therapy.
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Ondrušová, Ľubica Vachtenheim, Jiří
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.5772/55191
http://purl.org/ne...btex#hasPublisher	InTech
https://schema.org/isbn	978-953-51-0976-1
http://localhost/t...ganizacniJednotka	11110

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