About: Global Features of Gene Expression on the Proteome and Transcriptome Levels in S-coelicolor during Germination

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About: Global Features of Gene Expression on the Proteome and Transcriptome Levels in S-coelicolor during Germination Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1371/journal.pone.0072842
Description	Streptomycetes have been studied mostly as producers of secondary metabolites, while the transition from dormant spores to an exponentially growing culture has largely been ignored. Here, we focus on a comparative analysis of fluorescently and radioactively labeled proteome and microarray acquired transcriptome expressed during the germination of Streptomyces coelicolor. The time-dynamics is considered, starting from dormant spores through 5.5 hours of growth with 13 time points. Time series of the gene expressions were analyzed using correlation, principal components analysis and an analysis of coding genes utilization. Principal component analysis was used to identify principal kinetic trends in gene expression and the corresponding genes driving S. coelicolor germination. In contrast with the correlation analysis, global trends in the gene/protein expression reflected by the first principal components showed that the prominent patterns in both the protein and the mRNA domains are surprisingly well correlated. Analysis of the number of expressed genes identified functional groups activated during different time intervals of the germination. Streptomycetes have been studied mostly as producers of secondary metabolites, while the transition from dormant spores to an exponentially growing culture has largely been ignored. Here, we focus on a comparative analysis of fluorescently and radioactively labeled proteome and microarray acquired transcriptome expressed during the germination of Streptomyces coelicolor. The time-dynamics is considered, starting from dormant spores through 5.5 hours of growth with 13 time points. Time series of the gene expressions were analyzed using correlation, principal components analysis and an analysis of coding genes utilization. Principal component analysis was used to identify principal kinetic trends in gene expression and the corresponding genes driving S. coelicolor germination. In contrast with the correlation analysis, global trends in the gene/protein expression reflected by the first principal components showed that the prominent patterns in both the protein and the mRNA domains are surprisingly well correlated. Analysis of the number of expressed genes identified functional groups activated during different time intervals of the germination. (en)
Title	Global Features of Gene Expression on the Proteome and Transcriptome Levels in S-coelicolor during Germination Global Features of Gene Expression on the Proteome and Transcriptome Levels in S-coelicolor during Germination (en)
skos:prefLabel	Global Features of Gene Expression on the Proteome and Transcriptome Levels in S-coelicolor during Germination Global Features of Gene Expression on the Proteome and Transcriptome Levels in S-coelicolor during Germination (en)
skos:notation	RIV/00216208:11110/13:10190164!RIV14-GA0-11110___
http://linked.open...avai/predkladatel	1. lékařská fakulta
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GAP302/10/0468), P(GAP302/11/0229), S
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Bobek, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	76656
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/13:10190164
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	activation; granaticolor; a3(2); aerial spores; oxidative stress; bacillus-subtilis; messenger-rna; sigma-factor; streptomyces-coelicolor; singular-value decomposition (en)
http://linked.open.../riv/klicoveSlovo	activation bacillus-subtilis messenger-rna oxidative stress a3(2) aerial spores granaticolor sigma-factor singular-value decomposition streptomyces-coelicolor
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[57DC6C7EE78D]
http://linked.open...i/riv/nazevZdroje	PLoS ONE
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Systems biology of streptomyces germination Analysis and modelling of gene expression in search for regulatory RNAs affecting antibiotic production in Streptomyces
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Bobek, Jan Strakova, Eva Vohradsky, Jiří Zikova, Alice
http://linked.open...ain/vavai/riv/wos	000326405300031
issn	1932-6203
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pone.0072842
http://localhost/t...ganizacniJednotka	11110

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