About: Availability of Haematopoietic Niches for Transplanted Stem Cells

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://fb.cuni.cz/file/5666/FB2013A0001.pdf
Description	Following transplantation, donor haematopoietic stem cells (HSCs) must reach specific parts of haematopoietic stroma tissue known as stem cell niches to become engrafted and to start blood cell production. Regularly, they have to compete with the host's HSCs for a limited number of niches. The exact mechanisms of HSC engraftment as well as of niche %22opening%22 to incoming HSCs by conditioning treatments are not well-known yet. Significant and stable engraftment of syngeneic donor HSCs can be achieved in untreated mice only after transplantation of very large numbers of marrow cells. Engraftment can be largely facilitated by the stem cell mutations reducing numbers of the host HSCs. Pre-transplantation manipulations of the host haematopoietic tissue enhance engraftment depending on how much they damage HSCs. Ionizing radiation appears to be the most effective in this respect despite proliferative quiescence of a majority of HSCs. The review summarizes major achievements in deciphering biological principles of the HSCs and their engraftment after transplantation obtained in experimental research studying murine haematopoiesis. Following transplantation, donor haematopoietic stem cells (HSCs) must reach specific parts of haematopoietic stroma tissue known as stem cell niches to become engrafted and to start blood cell production. Regularly, they have to compete with the host's HSCs for a limited number of niches. The exact mechanisms of HSC engraftment as well as of niche %22opening%22 to incoming HSCs by conditioning treatments are not well-known yet. Significant and stable engraftment of syngeneic donor HSCs can be achieved in untreated mice only after transplantation of very large numbers of marrow cells. Engraftment can be largely facilitated by the stem cell mutations reducing numbers of the host HSCs. Pre-transplantation manipulations of the host haematopoietic tissue enhance engraftment depending on how much they damage HSCs. Ionizing radiation appears to be the most effective in this respect despite proliferative quiescence of a majority of HSCs. The review summarizes major achievements in deciphering biological principles of the HSCs and their engraftment after transplantation obtained in experimental research studying murine haematopoiesis. (en)
Title	Availability of Haematopoietic Niches for Transplanted Stem Cells Availability of Haematopoietic Niches for Transplanted Stem Cells (en)
skos:prefLabel	Availability of Haematopoietic Niches for Transplanted Stem Cells Availability of Haematopoietic Niches for Transplanted Stem Cells (en)
skos:notation	RIV/00216208:11110/13:10189439!RIV14-MSM-11110___
http://linked.open...avai/predkladatel	1. lékařská fakulta
http://linked.open...avai/riv/aktivita	I S
http://linked.open...avai/riv/aktivity	I, S
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Nečas, Emanuel Forgáčová, Katarína
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	62733
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/13:10189439
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	stem cell mutations; engraftment; cytostatics; irradiation; bone marrow transplantation; niche; progenitors; haematopoietic stem cell; haematopoiesis; mouse (en)
http://linked.open.../riv/klicoveSlovo	haematopoietic stem cell stem cell mutations cytostatics niche engraftment bone marrow transplantation progenitors irradiation mouse haematopoiesis
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[ED02F9716758]
http://linked.open...i/riv/nazevZdroje	Folia Biologica
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Forgáčová, Katarína Nečas, Emanuel
http://linked.open...ain/vavai/riv/wos	000326215200001
issn	0015-5500
number of pages	14 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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