About: PEG-Modified Macroporous Poly(Glycidyl Methacrylate) and Poly(2-Hydroxyethyl Methacrylate) Microspheres to Reduce Non-Specific Protein Adsorption

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About: PEG-Modified Macroporous Poly(Glycidyl Methacrylate) and Poly(2-Hydroxyethyl Methacrylate) Microspheres to Reduce Non-Specific Protein Adsorption Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1002/mabi.201200446
Description	To minimize non-specific protein adsorption on macroporous poly(glycidyl methacrylate) and poly(2-hydroxyethyl methacrylate) microspheres containing amino and/or carboxyl groups, the microspheres are coated with ,-bis-carboxy poly(ethylene glycol) and amino-terminated poly(ethylene glycol-co-propylene glycol) or -methoxy--amino poly(ethylene glycol). Adsorption of bovine serum albumin (BSA), -globulin, 125I-BSA, pepsin, and chymotrypsin on neat and PEGylated microspheres is determined by UVVIS spectroscopy of supernatants and eluates or by measurement of radioactivity in an ionization chamber. Neat and PEGylated microspheres adsorb 0.870% and 0.0244% of protein, respectively. To minimize non-specific protein adsorption on macroporous poly(glycidyl methacrylate) and poly(2-hydroxyethyl methacrylate) microspheres containing amino and/or carboxyl groups, the microspheres are coated with ,-bis-carboxy poly(ethylene glycol) and amino-terminated poly(ethylene glycol-co-propylene glycol) or -methoxy--amino poly(ethylene glycol). Adsorption of bovine serum albumin (BSA), -globulin, 125I-BSA, pepsin, and chymotrypsin on neat and PEGylated microspheres is determined by UVVIS spectroscopy of supernatants and eluates or by measurement of radioactivity in an ionization chamber. Neat and PEGylated microspheres adsorb 0.870% and 0.0244% of protein, respectively. (en)
Title	PEG-Modified Macroporous Poly(Glycidyl Methacrylate) and Poly(2-Hydroxyethyl Methacrylate) Microspheres to Reduce Non-Specific Protein Adsorption PEG-Modified Macroporous Poly(Glycidyl Methacrylate) and Poly(2-Hydroxyethyl Methacrylate) Microspheres to Reduce Non-Specific Protein Adsorption (en)
skos:prefLabel	PEG-Modified Macroporous Poly(Glycidyl Methacrylate) and Poly(2-Hydroxyethyl Methacrylate) Microspheres to Reduce Non-Specific Protein Adsorption PEG-Modified Macroporous Poly(Glycidyl Methacrylate) and Poly(2-Hydroxyethyl Methacrylate) Microspheres to Reduce Non-Specific Protein Adsorption (en)
skos:notation	RIV/00216208:11110/13:10189371!RIV14-GA0-11110___
http://linked.open...avai/predkladatel	1. lékařská fakulta
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(7E12053), P(GAP206/12/0381), P(GCP207/12/J013)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kučerová, Zdenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	95665
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/13:10189371
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	poly(ethylene glycol); morphology; 2-hydroxyethyl methacrylate; glycidyl methacrylate; coatings (en)
http://linked.open.../riv/klicoveSlovo	glycidyl methacrylate morphology poly(ethylene glycol) 2-hydroxyethyl methacrylate coatings
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[984B2A516B06]
http://linked.open...i/riv/nazevZdroje	Macromolecular Bioscience
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of ultrasensitive electrochemical immunosensors for early detection of clinically significant biomarkers of malignant diseases Innovative multifunctional magnetic nano- and microparticles for cell diagnostics Nanosystems for early Diagnosis of Neurodegenerative Diseases
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Kučerová, Zdenka Kucka, Jan Hlidkova, Helena Horak, Daniel Pekarek, Michal Proks, Vladimir
http://linked.open...ain/vavai/riv/wos	000318043400012
issn	1616-5187
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/mabi.201200446
http://localhost/t...ganizacniJednotka	11110

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