About: Comparative Analysis of IL-8 and CXCL-1 Production by Normal and Cancer Stromal Fibroblasts

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About: Comparative Analysis of IL-8 and CXCL-1 Production by Normal and Cancer Stromal Fibroblasts Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://fb.cuni.cz/file/5691/FB2013A0018.pdf
Description	It has been shown that fibroblasts within the stroma of malignant tumours can affect the tumour's biological character, influencing such properties as local aggressiveness and metastasis potential. This influence is asserted via paracrine secretion of multiple cell factors, including chemokines. This study demonstrates that both normal keratinocytes and cancer cells can stimulate the secretion of chemokines IL-8 and CXCL-1 from normal dermal fibroblasts and stromal fibroblasts from squamous cell carcinoma. The effect of epithelia on normal fibroblasts leads to a transient secretory change, in contrast to stromal fibroblasts which generate a more prolonged one. This observation demonstrates that stimulated expression of both IL-8 and CXCL-1 is not specific to cancer, supporting the hypothesis that similar mechanisms exist between wound healing and oncogenesis. It also shows that stromal fibroblasts isolated from a tumour have significantly different features from normal fibroblasts. It has been shown that fibroblasts within the stroma of malignant tumours can affect the tumour's biological character, influencing such properties as local aggressiveness and metastasis potential. This influence is asserted via paracrine secretion of multiple cell factors, including chemokines. This study demonstrates that both normal keratinocytes and cancer cells can stimulate the secretion of chemokines IL-8 and CXCL-1 from normal dermal fibroblasts and stromal fibroblasts from squamous cell carcinoma. The effect of epithelia on normal fibroblasts leads to a transient secretory change, in contrast to stromal fibroblasts which generate a more prolonged one. This observation demonstrates that stimulated expression of both IL-8 and CXCL-1 is not specific to cancer, supporting the hypothesis that similar mechanisms exist between wound healing and oncogenesis. It also shows that stromal fibroblasts isolated from a tumour have significantly different features from normal fibroblasts. (en)
Title	Comparative Analysis of IL-8 and CXCL-1 Production by Normal and Cancer Stromal Fibroblasts Comparative Analysis of IL-8 and CXCL-1 Production by Normal and Cancer Stromal Fibroblasts (en)
skos:prefLabel	Comparative Analysis of IL-8 and CXCL-1 Production by Normal and Cancer Stromal Fibroblasts Comparative Analysis of IL-8 and CXCL-1 Production by Normal and Cancer Stromal Fibroblasts (en)
skos:notation	RIV/00216208:11110/13:10174094!RIV14-MZ0-11110___
http://linked.open...avai/predkladatel	1. lékařská fakulta
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(NT13488), S
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Smetana, Karel Szabo, Pavol Dvořánková, Barbora Valach, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	66070
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/13:10174094
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	head; origin; phenotype; tumors; normal keratinocytes; squamous-cell carcinoma (en)
http://linked.open.../riv/klicoveSlovo	squamous-cell carcinoma tumors origin phenotype normal keratinocytes head
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[62F5A7764EE2]
http://linked.open...i/riv/nazevZdroje	Folia Biologica
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Genomic analysis of tumor-associated fibroblasts in head and neck carcinoma: The basis for new generation of biologic anti-tumor therapy
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Dvořánková, Barbora Smetana, Karel Valach, Jaroslav Szabo, Pavol
http://linked.open...ain/vavai/riv/wos	000322419900006
issn	0015-5500
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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