About: MITF meets chromatin in melanoma

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	https://www.novapublishers.com/catalog/product_info.php?products_id=37164
Description	SWI/SNF chromatin remodeling complexes contain either Brm (Brahma) or Brg1 (Brahma-related gene 1) as the ATPase subunits. MITF (microphthalmia-associated transcription factor) is a pivotal protein required for the survival and proliferation of normal melanocytes and melanoma cells. MITF activates transcription of many genes regulating proliferation, apoptosis and invasiveness of melanoma cells and is a potential target for gene therapy of melanoma, an aggressive malignant tumor for which no effective therapy exists when metastases occur. Expression of MITF is absolutely dependent on this the SWI/SNF complex, and both Brg1- or Brm-containing complexes are sufficient to support MITF gene transcription. Additionally, especially Brg1 complex seems to support tumor growth even independently of the MITF axis. Thus, SWI/SNF complexes appear to be crucial determinants of melanoma development and progression. SWI/SNF chromatin remodeling complexes contain either Brm (Brahma) or Brg1 (Brahma-related gene 1) as the ATPase subunits. MITF (microphthalmia-associated transcription factor) is a pivotal protein required for the survival and proliferation of normal melanocytes and melanoma cells. MITF activates transcription of many genes regulating proliferation, apoptosis and invasiveness of melanoma cells and is a potential target for gene therapy of melanoma, an aggressive malignant tumor for which no effective therapy exists when metastases occur. Expression of MITF is absolutely dependent on this the SWI/SNF complex, and both Brg1- or Brm-containing complexes are sufficient to support MITF gene transcription. Additionally, especially Brg1 complex seems to support tumor growth even independently of the MITF axis. Thus, SWI/SNF complexes appear to be crucial determinants of melanoma development and progression. (en)
Title	MITF meets chromatin in melanoma MITF meets chromatin in melanoma (en)
skos:prefLabel	MITF meets chromatin in melanoma MITF meets chromatin in melanoma (en)
skos:notation	RIV/00216208:11110/12:12847!RIV13-MZ0-11110___
http://linked.open...avai/predkladatel	1. lékařská fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NT11229)
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Ondrušová, Ľubica Vachtenheim, Jiří
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	150734
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/12:12847
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	SWI/SNF; MITF; melanoma; Brg1; Brm; INI1 (en)
http://linked.open.../riv/klicoveSlovo	MITF Brg1 Brm INI1 SWI/SNF melanoma
http://linked.open...ontrolniKodProRIV	[FE6E7FE5A5CE]
http://linked.open...i/riv/mistoVydani	New York
http://linked.open...vEdiceCisloSvazku	Cell Biology Research Progress
http://linked.open...i/riv/nazevZdroje	New Developments in Chromatin Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...v/pocetStranKnihy	247 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Transcription factor MITF – critical regulator of proliferation and viability of melanoma cells and a target of molecular anticancer therapy.
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Ondrušová, Ľubica Vachtenheim, Jiří
number of pages	18 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Nova Science Publishers
https://schema.org/isbn	978-1-62081-816-9
http://localhost/t...ganizacniJednotka	11110
is http://linked.open...avai/riv/vysledek of	MITF meets chromatin in melanoma

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