About: Interactions of a Hydrophobically Modified Polycation with Zwitterionic Lipid Membranes     Goto   Sponge   NotDistinct   Permalink

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Description
  • We have studied the impact of a hydrophobically modified strong polycation on the properties of a zwitterionic bilayer used as a model of the mammalian cellular membrane. Our results have shown that a new polycation, poly(allyl-N,Ndimethyl-N-hexylammonium chloride) can efficiently associate with and insert into the phosphocholine membrane without changing its lamellar structure. However, its binding promotes formation of hydrophilic pores in the membrane, thus increasing considerably its permeability.
  • We have studied the impact of a hydrophobically modified strong polycation on the properties of a zwitterionic bilayer used as a model of the mammalian cellular membrane. Our results have shown that a new polycation, poly(allyl-N,Ndimethyl-N-hexylammonium chloride) can efficiently associate with and insert into the phosphocholine membrane without changing its lamellar structure. However, its binding promotes formation of hydrophilic pores in the membrane, thus increasing considerably its permeability. (en)
Title
  • Interactions of a Hydrophobically Modified Polycation with Zwitterionic Lipid Membranes
  • Interactions of a Hydrophobically Modified Polycation with Zwitterionic Lipid Membranes (en)
skos:prefLabel
  • Interactions of a Hydrophobically Modified Polycation with Zwitterionic Lipid Membranes
  • Interactions of a Hydrophobically Modified Polycation with Zwitterionic Lipid Membranes (en)
skos:notation
  • RIV/00216208:11110/12:12791!RIV13-MSM-11110___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(LC535), Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
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http://linked.open...dnocenehoVysledku
  • 142286
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11110/12:12791
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • phosphocholine membrane; permeability; hydrophobically modified polycation; cryo-electron microscopy; molecular modelling (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [068B0109AB0B]
http://linked.open...i/riv/nazevZdroje
  • Langmuir
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http://linked.open...v/svazekPeriodika
  • 28
http://linked.open...iv/tvurceVysledku
  • Bednár, Ján
  • Kepczynski, Mariusz
  • Jamroz, Dorota
  • Nowakowska, M.
  • Rzad, E.
  • Wytrwal, Magdalena
http://linked.open...ain/vavai/riv/wos
  • 000298904900086
http://linked.open...n/vavai/riv/zamer
issn
  • 0743-7463
number of pages
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  • 11110
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