About: A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1093/hmg/ddr479
Description	Renal cell carcinoma (RCC) is the most lethal urologic cancer. Only two common susceptibility loci for RCC have been confirmed to date. To identify additional RCC common susceptibility loci, we conducted an independent genome- wide association study (GWAS). We analyzed 533 191 single nucleotide polymorphisms (SNPs) for association with RCC in 894 cases and 1516 controls of European descent recruited from MD Anderson Cancer Center in the primary scan, and validated the top 500 SNPs in silico in 3772 cases and 8505 controls of European descent involved in the only published GWAS of RCC. It has been recently identified that one of the variants, rs718314 in ITPR2 is associated with waist-hip ratio (WHR) phenotype. To our knowledge, this is the first genetic locus associated with both cancer risk and WHR. Renal cell carcinoma (RCC) is the most lethal urologic cancer. Only two common susceptibility loci for RCC have been confirmed to date. To identify additional RCC common susceptibility loci, we conducted an independent genome- wide association study (GWAS). We analyzed 533 191 single nucleotide polymorphisms (SNPs) for association with RCC in 894 cases and 1516 controls of European descent recruited from MD Anderson Cancer Center in the primary scan, and validated the top 500 SNPs in silico in 3772 cases and 8505 controls of European descent involved in the only published GWAS of RCC. It has been recently identified that one of the variants, rs718314 in ITPR2 is associated with waist-hip ratio (WHR) phenotype. To our knowledge, this is the first genetic locus associated with both cancer risk and WHR. (en)
Title	A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23 A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23 (en)
skos:prefLabel	A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23 A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23 (en)
skos:notation	RIV/00216208:11110/12:12005!RIV13-MSM-11110___
http://linked.open...avai/predkladatel	1. lékařská fakulta
http://linked.open...avai/riv/aktivita	N R
http://linked.open...avai/riv/aktivity	N, R
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Bencko, Vladimír Holcátová, Ivana Slámová, Alena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	120234
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/12:12005
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	postmenopausal women; kidney cancer; risk-factors; body-size; epidemiology; metaanalysis; type-2 (en)
http://linked.open.../riv/klicoveSlovo	body-size type-2 epidemiology kidney cancer metaanalysis risk-factors postmenopausal women
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[48ABB75CAFB7]
http://linked.open...i/riv/nazevZdroje	Human Molecular Genetics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	92 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Bencko, Vladimír Holcátová, Ivana Johansson, M. Fabianova, E. Lissowska, J. Mates, D. Szeszenia-Dabrowska, N. Zaridze, D. Rudnai, P. Slámová, Alena Chow, W. H. Gaborieau, V. Jacobs, K. B. Jinga, V. Lin, J. Lubinski, J. Moore, L. E. Prokhortchouk, E. Purdue, M. P. Rothman, N. Scelo, G. Toro, J. R. Trubicka, J. Wang, Z. M. Wood, C. G. Wu, X. F. Ye, Y. Q. Zelenika, D.
http://linked.open...ain/vavai/riv/wos	000298658300019
issn	0964-6906
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11110
is http://linked.open...avai/riv/vysledek of	A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23

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