About: Influence of Allopurinol on Evoked Cortical Afterdischarges During Early Ontogenesis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.biomed.cas.cz/physiolres/pdf/61%20Suppl%202/61_S111.pdf
Description	The aim of our study was to test the hypothesis, whether repeated allopurinol pre-treatment (in dose of 135 mg/kg s.c.) can influence changes of brain excitability caused by long-term hypoxia exposition in young immature rats. Rat pups were exposed together with their mother in to an intermittent hypobaric hypoxia (simulated altitude of 7 000 m) since the day of birth till the 11th day (youngest experimental group) or 17th day for 8 hours a day. Allopurinol was administered daily immediately before each hypoxia exposition. The duration of evoked afterdischarges (ADs) and the shape of evoked graphoelements were evaluated in 12, 18, 25 and 35-day-old freely moving male pups. Hypobaric hypoxia prolonged the duration of ADs in 12, 18 and 25-day-old rats. The ADs were prolonged in 35-day-old rats only after the first stimulation. Allopurinol shorted the duration of ADs only in 12-day-old pups. In older experimental group the effect of allopurinol treatment was less pronounced. The aim of our study was to test the hypothesis, whether repeated allopurinol pre-treatment (in dose of 135 mg/kg s.c.) can influence changes of brain excitability caused by long-term hypoxia exposition in young immature rats. Rat pups were exposed together with their mother in to an intermittent hypobaric hypoxia (simulated altitude of 7 000 m) since the day of birth till the 11th day (youngest experimental group) or 17th day for 8 hours a day. Allopurinol was administered daily immediately before each hypoxia exposition. The duration of evoked afterdischarges (ADs) and the shape of evoked graphoelements were evaluated in 12, 18, 25 and 35-day-old freely moving male pups. Hypobaric hypoxia prolonged the duration of ADs in 12, 18 and 25-day-old rats. The ADs were prolonged in 35-day-old rats only after the first stimulation. Allopurinol shorted the duration of ADs only in 12-day-old pups. In older experimental group the effect of allopurinol treatment was less pronounced. (en)
Title	Influence of Allopurinol on Evoked Cortical Afterdischarges During Early Ontogenesis Influence of Allopurinol on Evoked Cortical Afterdischarges During Early Ontogenesis (en)
skos:prefLabel	Influence of Allopurinol on Evoked Cortical Afterdischarges During Early Ontogenesis Influence of Allopurinol on Evoked Cortical Afterdischarges During Early Ontogenesis (en)
skos:notation	RIV/00216208:11110/12:11469!RIV13-GA0-11110___
http://linked.open...avai/predkladatel	1. lékařská fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GP305/09/P136)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Riljak, Vladimír Marešová, Dana Pokorný, Jaroslav Jandová, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	141325
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/12:11469
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Allopurinol; Hypoxia; Evoked potentials; Development; Rat; ischemic brain-damage; nitric-oxide synthase; cerebral-ischemia; xanthine-oxidase; short-term; hypoxia; oxypurinol; epilepsy; injury; inhibition (en)
http://linked.open.../riv/klicoveSlovo	Hypoxia hypoxia inhibition Development epilepsy Rat Allopurinol Evoked potentials ischemic brain-damage nitric-oxide synthase oxypurinol short-term xanthine-oxidase injury cerebral-ischemia
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[CC1FBA693B5C]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Nicotine as a protective agent in neurodegenerative disorders - an ontogenetic study
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	61
http://linked.open...iv/tvurceVysledku	Pokorný, Jaroslav Marešová, Dana Riljak, Vladimír Jandová, Kateřina
http://linked.open...ain/vavai/riv/wos	000310260000013
issn	0862-8408
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11110
is http://linked.open...avai/riv/vysledek of	Influence of Allopurinol on Evoked Cortical Afterdischarges During Early Ontogenesis

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