About: Methods for Evaluation of Humoral Immune Responses in Human Genital Tract Secretions

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1111/j.1600-0897.2010.00923.x
Description	The compilation of epidemiological, virological, and immunological data clearly indicates that HIV-1 infection must be considered primarily as a disease of the mucosal immune system. The earliest and most dramatic alterations of the immune system occur in the mucosal compartment. However, the mucosal immune systems of the genital and intestinal tracts display remarkable immunological differences that must be considered in the evaluation of humoral immune responses in HIV-1-infected individuals or in volunteers immunized with experimental HIV vaccines. In this regard, marked differences in the dominant Ig isotypes, molecular forms of HIV-1-specific antibodies, and their distinct effector functions in the genital versus intestinal tracts must be carefully evaluated and considered in the measurement and interpretation of humoral immune responses. The compilation of epidemiological, virological, and immunological data clearly indicates that HIV-1 infection must be considered primarily as a disease of the mucosal immune system. The earliest and most dramatic alterations of the immune system occur in the mucosal compartment. However, the mucosal immune systems of the genital and intestinal tracts display remarkable immunological differences that must be considered in the evaluation of humoral immune responses in HIV-1-infected individuals or in volunteers immunized with experimental HIV vaccines. In this regard, marked differences in the dominant Ig isotypes, molecular forms of HIV-1-specific antibodies, and their distinct effector functions in the genital versus intestinal tracts must be carefully evaluated and considered in the measurement and interpretation of humoral immune responses. (en)
Title	Methods for Evaluation of Humoral Immune Responses in Human Genital Tract Secretions Methods for Evaluation of Humoral Immune Responses in Human Genital Tract Secretions (en)
skos:prefLabel	Methods for Evaluation of Humoral Immune Responses in Human Genital Tract Secretions Methods for Evaluation of Humoral Immune Responses in Human Genital Tract Secretions (en)
skos:notation	RIV/00216208:11110/11:9001!RIV12-MSM-11110___
http://linked.open...avai/predkladatel	1. lékařská fakulta
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Městecký, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	211813
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/11:9001
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antibodies; external secretions; HIV; mucosal immunity (en)
http://linked.open.../riv/klicoveSlovo	antibodies HIV external secretions mucosal immunity
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5F7159CEB057]
http://linked.open...i/riv/nazevZdroje	American Journal of Reproductive Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	65
http://linked.open...iv/tvurceVysledku	Moldoveanu, Zina Alexander, Rashada C. Městecký, Jiří Wei, Qing
http://linked.open...ain/vavai/riv/wos	000287037200024
issn	1046-7408
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11110
is http://linked.open...avai/riv/vysledek of	Methods for Evaluation of Humoral Immune Responses in Human Genital Tract Secretions Methods for Evaluation of Humoral Immune Responses in Human Genital Tract Secretions

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