About: A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains

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About: A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Endogenous retroviruses (ERVs) contribute to a range of mutations in mammals. However, autonomous retrotransposition of ERV has not been demonstrated in the rat genome. We cloned an insertion that disrupted Cntrob gene and identified it as a novel endogenous retrovirus (RnERV-K8e family). This family is closely related to the recently reported MmERV-K10c elements. We also identified a novel, unexpectedly close relative of RnERV-K8e in the mouse, suggesting cross-species transmission. We cloned a potentially autonomous RnERV-K8e element demonstrated that it is capable of retrotransposition. This particular element encodes an envelope gene (env), which is not required for retrotransposition. A number of RnERV-K8e-associated genetic polymorphisms was detected among inbred rat strains, suggesting ongoing activity in the rat genome. Ongoing retrotranspositional activity may significantly add to genomic variability among inbred rat strains. Endogenous retroviruses (ERVs) contribute to a range of mutations in mammals. However, autonomous retrotransposition of ERV has not been demonstrated in the rat genome. We cloned an insertion that disrupted Cntrob gene and identified it as a novel endogenous retrovirus (RnERV-K8e family). This family is closely related to the recently reported MmERV-K10c elements. We also identified a novel, unexpectedly close relative of RnERV-K8e in the mouse, suggesting cross-species transmission. We cloned a potentially autonomous RnERV-K8e element demonstrated that it is capable of retrotransposition. This particular element encodes an envelope gene (env), which is not required for retrotransposition. A number of RnERV-K8e-associated genetic polymorphisms was detected among inbred rat strains, suggesting ongoing activity in the rat genome. Ongoing retrotranspositional activity may significantly add to genomic variability among inbred rat strains. (en)
Title	A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains (en)
skos:prefLabel	A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains (en)
skos:notation	RIV/00216208:11110/10:7144!RIV11-GA0-11110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA304/06/0116), P(GP301/07/P178)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Liška, František Křen, Vladimír Křenová, Drahomíra Šedová, Lucie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	244813
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/10:7144
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	rat genomics; autonomous retrotransposons; endogenous retroviruses; genetic variability; insertional mutagenesis; centrobin (en)
http://linked.open.../riv/klicoveSlovo	genetic variability insertional mutagenesis autonomous retrotransposons centrobin endogenous retroviruses rat genomics
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E150A50359F6]
http://linked.open...i/riv/nazevZdroje	Genome research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Genes influencing limb patterning: morphology and functional genomics of hypodactyly and polydactyly-luxate mutations in the Norway rat Spermatogenesis impairment in the rats carrying the mutant allele hd: analysis of molecular function of both normal and mutant allele of the LOC303240
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Křen, Vladimír Hubner, N. Liška, František Křenová, Drahomíra Šedová, Lucie Wang, Y. M. Ivics, Z. Gosele, C. Izsvak, Z.
http://linked.open...ain/vavai/riv/wos	000273249500003
issn	1088-9051
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	11110
is http://linked.open...avai/riv/vysledek of	A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains

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