About: Detection of DPYD*2A allele in dihydropyrimidine dehydrogenase gene: perspective for fluoropyrimidine-treated patients

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About: Detection of DPYD*2A allele in dihydropyrimidine dehydrogenase gene: perspective for fluoropyrimidine-treated patients Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.mzm.cz/fileadmin/user_upload/publikace/casopisy/fm_49_2_2013/fm-2-2013-abstract-09.pdf
Description	Dihydropyrimidine dehydrogenase is a key enzyme involved in the metabolism of fluoropyrimidine anticancer drugs. Several studies have demonstrated that diminished DPD activity as a consequence of genetic variations in the DPYD gene limits carrier´s ability to fully metabolize the drug, resulting in toxicity and adverse events. DPYD2A (IVS14+1G > A) represents the most abundant variant allele in the European Caucasian population. Cancer patients with this gene variant represent a subgroup with higher risk of toxicity when treated with fluoropyrimidines. Therefore, we have implemented a method for DPYD2A allele genotyping. In our pilot study performed in a group of individuals derived from our regional reference population, we found that none out of 47 subjects was a carrier of the DPYD2A variant allele. Dihydropyrimidine dehydrogenase is a key enzyme involved in the metabolism of fluoropyrimidine anticancer drugs. Several studies have demonstrated that diminished DPD activity as a consequence of genetic variations in the DPYD gene limits carrier´s ability to fully metabolize the drug, resulting in toxicity and adverse events. DPYD2A (IVS14+1G > A) represents the most abundant variant allele in the European Caucasian population. Cancer patients with this gene variant represent a subgroup with higher risk of toxicity when treated with fluoropyrimidines. Therefore, we have implemented a method for DPYD2A allele genotyping. In our pilot study performed in a group of individuals derived from our regional reference population, we found that none out of 47 subjects was a carrier of the DPYD2A variant allele. (en)
Title	Detection of DPYD2A allele in dihydropyrimidine dehydrogenase gene: perspective for fluoropyrimidine-treated patients Detection of DPYD2A allele in dihydropyrimidine dehydrogenase gene: perspective for fluoropyrimidine-treated patients (en)
skos:prefLabel	Detection of DPYD2A allele in dihydropyrimidine dehydrogenase gene: perspective for fluoropyrimidine-treated patients Detection of DPYD2A allele in dihydropyrimidine dehydrogenase gene: perspective for fluoropyrimidine-treated patients (en)
skos:notation	RIV/00209805:_____/13:#0000446!RIV14-MZ0-00209805
http://linked.open...avai/predkladatel	Masarykův onkologický ústav
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED2.1.00/03.0101), P(LM2010004)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Valík, Dalibor Dubská, Lenka Vyskočilová, Martina Pilátová, Kateřina Obermannová, Radka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	68727
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/13:#0000446
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DPD genotyping; polymorphism; fluoropyrimidines; toxicity (en)
http://linked.open.../riv/klicoveSlovo	DPD genotyping polymorphism toxicity fluoropyrimidines
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[C73279AC489A]
http://linked.open...i/riv/nazevZdroje	Folia Mendeliana
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	BBMRI_CZ in the building of the Czech part of a large distributed research infrastructure of pan-European importance: the creation and operation of the network of banks of biological material for biomedical research Regional Centre for Applied Molecular Oncology (RECAMO)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	49
http://linked.open...iv/tvurceVysledku	Valík, Dalibor Mrkvicová, Martina Pilátová, Kateřina Zdražilová Dubská, Lenka Obermannová, Radka
issn	0085-0748
number of pages	6 (xsd:int)

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