About: Tumor hypoxia and its clinical significance

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Tumor hypoxia and its clinical significance Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.mzm.cz/fileadmin/user_upload/publikace/casopisy/fm_49_2_2013/fm-2-2013-abstract-08.pdf
Description	In the light of intense cancer research, the tumor microenvironment has become a matter of great interest as it can influence many different aspects of tumor progression including growth, metastatic potential and response to treatment. In that field, low oxygen pressure (hypoxia), which evolves from uncontrollable growth and poor vasculature, plays a significant role. The main executer of tumor cell responses to hypoxia is a transcription factor HIF-1 (hypoxia-inducible factor 1), which triggers molecular adjustments helping cells to overcome those unfavorable conditions. It is also known that hypoxia renders cells resistant to treatment and in consequence affects patient outcome. This review focuses on HIF-1-dependent adaptations to insufficient oxygen delivery as well as describing clinical problems arising from hypoxia. Lastly, it highlights importance of targeted therapy aiming at hypoxic pathways. In the light of intense cancer research, the tumor microenvironment has become a matter of great interest as it can influence many different aspects of tumor progression including growth, metastatic potential and response to treatment. In that field, low oxygen pressure (hypoxia), which evolves from uncontrollable growth and poor vasculature, plays a significant role. The main executer of tumor cell responses to hypoxia is a transcription factor HIF-1 (hypoxia-inducible factor 1), which triggers molecular adjustments helping cells to overcome those unfavorable conditions. It is also known that hypoxia renders cells resistant to treatment and in consequence affects patient outcome. This review focuses on HIF-1-dependent adaptations to insufficient oxygen delivery as well as describing clinical problems arising from hypoxia. Lastly, it highlights importance of targeted therapy aiming at hypoxic pathways. (en)
Title	Tumor hypoxia and its clinical significance Tumor hypoxia and its clinical significance (en)
skos:prefLabel	Tumor hypoxia and its clinical significance Tumor hypoxia and its clinical significance (en)
skos:notation	RIV/00209805:_____/13:#0000445!RIV14-MZ0-00209805
http://linked.open...avai/predkladatel	Masarykův onkologický ústav
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED2.1.00/03.0101)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Hrstka, Roman Vojtěšek, Bořivoj Obacz, Joanna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	112007
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/13:#0000445
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HIF-1; resistance to therapy; hypoxic pathways (en)
http://linked.open.../riv/klicoveSlovo	HIF-1 hypoxic pathways resistance to therapy
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[6B41B55EFCC7]
http://linked.open...i/riv/nazevZdroje	Folia Mendeliana
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Regional Centre for Applied Molecular Oncology (RECAMO)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	49
http://linked.open...iv/tvurceVysledku	Hrstka, Roman Vojtěšek, Bořivoj Obacz, Joanna
issn	0085-0748
number of pages	5 (xsd:int)

Faceted Search & Find service v1.16.116 as of Feb 22 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of Feb 22 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 82 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software